HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: MKKS (Q9NPJ1)
Molecular chaperone MKKS (Bardet-Biedl syndrome 6 protein) (McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin)
Gene: MKKS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	20080638, 22500027
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~Cpn60_TCP1
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006457 - protein folding GO:0051082 - unfolded protein binding GO:0051131 - chaperone-mediated protein complex assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 570
+	Mm
		945916 TCPH_MOUSE (4-534): 0: 599: 33.77		TCPH_MOUSE (9-536): 6.93e-172: 499: 16.19
+	Hs
		943431 TCPB_HUMAN (1-535): 0: 586: 100.00		TCPH_HUMAN (9-531): 2.65e-167: 488: 16.21
+	Hs
		826843 TCPH_HUMAN (4-532): 0: 591: 34.08		TCPG_HUMAN (4-519): 7.61e-164: 479: 19.05
+	Hs
		821381 TCPH_HUMAN (4-532): 0: 591: 34.08		TCPE_HUMAN (1-516): 2.95e-162: 475: 15.54
+	Bt
		1102090 TCPB_BOVIN (1-535): 0: 582: 98.13		TCPH_BOVIN (9-529): 1.43e-165: 483: 15.91
+	Hs
		826618 TCPB_HUMAN (1-535): 0: 586: 100.00		TCPG_HUMAN (4-519): 7.61e-164: 479: 19.05
+	Hs
		821169 TCPB_HUMAN (1-535): 0: 586: 100.00		TCPE_HUMAN (1-516): 2.95e-162: 475: 15.54
+	Bt
		94406 TCPH_BOVIN (4-533): 0: 589: 32.90		F1MWD3_BOVIN (1-516): 1.53e-160: 470: 15.54
+	Bt
		94408 TCPB_BOVIN (1-535): 0: 582: 98.13		F1MWD3_BOVIN (1-516): 1.53e-160: 470: 15.54
+	Hs
		843351 TCPH_HUMAN (4-532): 0: 591: 34.08		TCPD_HUMAN (19-515): 4.97e-153: 451: 18.65
+	Ph
		223354 THS_PYRHO (1-523): 0: 572: 34.15		THS_PYRHO (6-521): 4.17e-160: 469: 17.86
+	Zm
		74215 B4FBP0_MAIZE (1-530): 0: 575: 32.28		B4FBP0_MAIZE (5-529): 1.62e-158: 466: 15.88
+	Hs
		843157 TCPB_HUMAN (1-535): 0: 586: 100.00		TCPD_HUMAN (19-515): 4.97e-153: 451: 18.65
+	Bt
		1102680 TCPB_BOVIN (1-535): 0: 582: 98.13		TCPD_BOVIN (19-515): 1.09e-150: 445: 18.27
+	Dm
		1367314 Q9W392_DROME (4-535): 0: 568: 70.73		Q9VHL2_DROME (6-523): 2.06e-150: 445: 15.63
+	Dm
		1180672 Q9W392_DROME (4-535): 0: 568: 70.73		Q7KKI0_DROME (5-516): 2.73e-150: 444: 16.39
+	Dm
		820692 Q9W392_DROME (4-535): 0: 568: 70.73		TCPG_DROME (6-490): 1.46e-136: 409: 18.32
+	Sc
		519941 TCPB_YEAST (9-532): 0: 566: 65.71		TCPA_YEAST (15-476): 3.58e-129: 391: 20.33
+	Sc
		760608 TCPB_YEAST (9-532): 0: 566: 65.71		TCPG_YEAST (24-490): 1.77e-120: 367: 16.70
+	Dm
		1369265 Q9W392_DROME (4-535): 0: 568: 70.73		Q9VK69_DROME (13-479): 2.08e-107: 334: 18.39