Protein: DSCR6
Protein ripply3 (Down syndrome critical region protein 6)

Gene: DSCR6, RIPPLY3
Organism: Homo sapiens
Interactions: 112
UniProt ID: P57055

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0007507 - heart development
GO:0008283 - cell population proliferation
GO:0008285 - negative regulation of cell population proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

943493

MCRS1
Microspherule protein 1

3

0

High-throughput

0.639

High

216148

TBX1
T-box transcription factor TBX1

2

0

Small-scale

0.585

High

633644

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

943472

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

943475

ORC2
Origin recognition complex subunit 2

2

0

High-throughput

0.580

High

943474

TRAF2
TNF receptor-associated factor 2

2

3

High-throughput

0.553

High

402891

ANXA1
Annexin A1

1

1

High-throughput

0.536

High

424168

S10A8
Protein S100-A8

1

6

High-throughput

0.536

High

444940

S10A9
Protein S100-A9

1

8

High-throughput

0.536

High

635577

FILA
Filaggrin

1

5

High-throughput

0.536

High

682474

S100P
Protein S100-P

1

8

High-throughput

0.536

High

686793

S10A4
Protein S100-A4

1

8

High-throughput

0.536

High

713352

SPB3
Serpin B3

1

7

High-throughput

0.536

High

724552

S10A7
Protein S100-A7

1

8

High-throughput

0.536

High

943464

FOXK1
Forkhead box protein K1

1

1

High-throughput

0.536

High

943465

FOXK2
Forkhead box protein K2

1

1

High-throughput

0.536

High

943467

TLE1
Transducin-like enhancer protein 1

1

19

High-throughput

0.536

High

943468

TLE2
Transducin-like enhancer protein 2

1

19

High-throughput

0.536

High

943469

TLE3
Transducin-like enhancer protein 3

1

19

High-throughput

0.536

High

943470

TLE4
Transducin-like enhancer protein 4

1

19

High-throughput

0.536

High

943471

TLE5
TLE family member 5

1

19

High-throughput

0.536

High

943494

S10AG
Protein S100-A16

1

8

High-throughput

0.536

High

133648

WASL
Actin nucleation-promoting factor WASL

1

0

High-throughput

0.518

High

389600

RET4
Retinol-binding protein 4

1

0

High-throughput

0.518

High

461321

HS90A
Heat shock protein HSP 90-alpha

1

0

High-throughput

0.518

High

472559

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.518

High

943487

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.518

High

126231

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

390002

ALBU
Albumin

1

0

High-throughput

0.513

High

423624

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

577682

PLAK
Junction plakoglobin

1

0

High-throughput

0.513

High

582565

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

671771

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

711697

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.513

High

729533

CASPE
Caspase-14

1

0

High-throughput

0.513

High

868665

LEG7
Galectin-7

1

0

High-throughput

0.513

High

870479

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.513

High

943476

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.513

High

943485

RDHE2
Epidermal retinol dehydrogenase 2

1

0

High-throughput

0.513

High

943507

NDRG2
Protein NDRG2

1

0

High-throughput

0.513

High

943461

IF4A1
Eukaryotic initiation factor 4A-I

1

1

High-throughput

0.494

High

943478

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.494

High

943498

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.494

High

85968

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

3

High-throughput

0.489

High

248687

PEPL
Periplakin

1

1

High-throughput

0.489

High

261613

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

289248

SPB7
Serpin B7

1

7

High-throughput

0.489

High

358880

AL1A1
Aldehyde dehydrogenase 1A1

1

1

High-throughput

0.489

High

369334

A1AT
Alpha-1-antitrypsin

1

6

High-throughput

0.489

High

369849

CO3
Complement C3

1

2

High-throughput

0.489

High

387813

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.489

High

387961

FIBG
Fibrinogen gamma chain

1

1

High-throughput

0.489

High

485786

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

568953

ANXA8
Annexin A8

1

1

High-throughput

0.489

High

721498

ILEU
Leukocyte elastase inhibitor

1

7

High-throughput

0.489

High

787625

SPB5
Serpin B5

1

7

High-throughput

0.489

High

868077

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.489

High

874769

SPB4
Serpin B4

1

7

High-throughput

0.489

High

895429

SPB8
Serpin B8

1

7

High-throughput

0.489

High

943463

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

943484

S1A7A
Protein S100-A7A

1

8

High-throughput

0.489

High

943488

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.489

High

943491

EVPL
Envoplakin

1

1

High-throughput

0.489

High

943499

S10AE
Protein S100-A14

1

8

High-throughput

0.489

High

943501

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.489

High

943504

SPB13
Serpin B13

1

7

High-throughput

0.489

High

403941

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

75663

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

2

High-throughput

0.437

High

69487

A2ML1
Alpha-2-macroglobulin-like protein 1

1

2

High-throughput

0.407

High

379086

IGKC
Immunoglobulin kappa constant

1

3

High-throughput

0.407

High

379235

IGHG1
Immunoglobulin heavy constant gamma 1

1

3

High-throughput

0.407

High

379344

IGHG2
Immunoglobulin heavy constant gamma 2

1

3

High-throughput

0.407

High

943492

TIFA
TRAF-interacting protein with FHA domain-containing protein A

3

0

High-throughput

0.346

High

291993

CRTAP
Cartilage-associated protein

2

0

High-throughput

0.330

High

943489

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

322714

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.282

High

348084

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

0

High-throughput

0.282

High

943462

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.282

High

943477

MLEC
Malectin

1

0

High-throughput

0.282

High

943486

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.282

High

943496

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.282

High

161868

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.279

Low

210735

KLK10
Kallikrein-10

1

0

High-throughput

0.279

Low

276574

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

389654

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.279

Low

390877

TRFE
Serotransferrin

1

0

High-throughput

0.279

Low

457851

INVO
Involucrin

1

0

High-throughput

0.279

Low

609300

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

615210

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.279

Low

627120

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

636172

ENDOU
Uridylate-specific endoribonuclease

1

0

High-throughput

0.279

Low

652298

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

692677

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

870640

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.279

Low

888507

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

943466

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.279

Low

943473

FP100
Fanconi anemia core complex-associated protein 100

1

0

High-throughput

0.279

Low

943479

SMTL2
Smoothelin-like protein 2

1

0

High-throughput

0.279

Low

943480

PA24E
Cytosolic phospholipase A2 epsilon

1

0

High-throughput

0.279

Low

943481

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

943482

RINL
Ras and Rab interactor-like protein

1

0

High-throughput

0.279

Low

943483

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

943490

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

943495

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

943497

MGST2
Microsomal glutathione S-transferase 2

1

0

High-throughput

0.279

Low

943500

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.279

Low

943502

DPP2
Dipeptidyl peptidase 2

1

0

High-throughput

0.279

Low

943503

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

943505

CLC4K
C-type lectin domain family 4 member K

1

0

High-throughput

0.279

Low

943506

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.279

Low

943508

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.279

Low

943509

FCGBP
IgGFc-binding protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025