HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	18498745, 33854235, 23045529
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1242 Hs			1 598
+	Hs
		724574 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		724572 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		1232715 PCLO_HUMAN (436-1242): 1.44e-22: 107: 8.92		FBXW8_HUMAN (1-598): 4.17e-132: 400: 96.17
+	Hs
		1356382 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		151893 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		TBL1R_HUMAN (62-239): 2.26e-13: 74.9: 14.05
+	Hs
		1281391 PRR36_HUMAN (223-826): 3.2e-09: 63.8: 13.22		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		903405 CBP_HUMAN (280-1238): 5.8e-36: 151: 12.68		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		903374 KMT2C_HUMAN (609-1203): 1.95e-12: 74.4: 14.29		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Dm
		1370339 Q9VLS7_DROME (239-918): 4.03e-13: 76.5: 7.93		FBXW7_DROME (460-598): 3.83e-25: 113: 17.01
+	Mm
		903669 KMT2C_MOUSE (266-1152): 1.32e-10: 68.7: 13.36		WDR5_MOUSE (463-590): 7.6e-28: 116: 12.69