HitPredict

Interactor 1: MP2K1 (P31938)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: Map2k1

Interactor 2: TRIB1 (Q8K4K4)
Tribbles homolog 1 (TRB-1)
Gene: TRIB1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20610816
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 393 Mm			1 372
+	Hs
		682166 CDK3_HUMAN (65-366): 3.68e-123: 359: 23.05		AKT2_HUMAN (26-371): 8.55e-136: 397: 20.56
+	Mm
		554868 MP2K1_MOUSE (1-393): 5.96e-126: 370: 100.00		KPCE_MOUSE (13-371): 3.69e-127: 384: 15.97
+	Hs
		623866 CDK2_HUMAN (65-367): 1.51e-126: 368: 24.60		KPCL_HUMAN (49-371): 5.12e-127: 381: 20.29
+	Mm
		682096 AKT1_MOUSE (39-389): 2.74e-119: 356: 19.72		AKT1_MOUSE (26-371): 1.47e-133: 391: 20.50
+	At
		955190 KIN10_ARATH (50-393): 7.85e-123: 366: 19.25		KIN11_ARATH (90-364): 4.63e-128: 379: 28.52
+	Hs
		972242 MP2K1_HUMAN (1-393): 7.25e-126: 369: 98.98		TRIB1_HUMAN (1-372): 4.4e-128: 374: 93.82
+	At
		1105318 KIN10_ARATH (50-393): 7.85e-123: 366: 19.25		KIN10_ARATH (76-364): 8.33e-127: 375: 28.19
+	At
		187503 KIN10_ARATH (50-393): 7.85e-123: 366: 19.25		CIPKB_ARATH (72-369): 7.96e-128: 375: 25.55
+	Hs
		414773 CDK1_HUMAN (65-366): 1.37e-119: 350: 24.60		AKT1_HUMAN (26-371): 7.19e-133: 390: 20.22
+	Mm
		554867 AKT1_MOUSE (39-389): 2.74e-119: 356: 19.72		KPCE_MOUSE (13-371): 3.69e-127: 384: 15.97
+	At
		187501 KIN11_ARATH (67-393): 3.53e-121: 362: 20.85		CIPKB_ARATH (72-369): 7.96e-128: 375: 25.55
+	Hs
		681681 AKT1_HUMAN (23-369): 4.11e-113: 340: 21.05		AKT2_HUMAN (26-371): 8.55e-136: 397: 20.56
+	Hs
		681680 AKT1_HUMAN (23-369): 4.11e-113: 340: 21.05		AKT1_HUMAN (26-371): 7.19e-133: 390: 20.22
+	Hs
		681799 AKT1_HUMAN (23-369): 4.11e-113: 340: 21.05		KPCT_HUMAN (21-371): 1.1e-125: 379: 19.61
+	Hs
		568561 AKT1_HUMAN (23-369): 4.11e-113: 340: 21.05		KAPCA_HUMAN (80-371): 7.04e-130: 377: 20.92
+	At
		249832 KIN10_ARATH (50-393): 7.85e-123: 366: 19.25		CIPK6_ARATH (73-371): 1.9e-108: 326: 28.57
+	At
		1106718 MPK7_ARATH (67-393): 1.22e-120: 355: 18.45		CIPKO_ARATH (89-350): 4.34e-108: 325: 28.83
+	Mm
		682120 AKT1_MOUSE (39-389): 2.74e-119: 356: 19.72		TRIB3_MOUSE (89-360): 8.03e-92: 281: 54.91
+	Hs
		972241 MP2K1_HUMAN (1-393): 7.25e-126: 369: 98.98		TRIB3_HUMAN (89-360): 1.83e-86: 267: 51.65