HitPredict

Interactor 1: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Interactor 2: MERTK (Q12866)
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Gene: MERTK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0006468 - protein phosphorylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 4128 Hs			1 999
+	Hs
		665578 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		EPHB2_HUMAN (28-991): 0: 653: 18.14
+	Hs
		600550 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		EPHA1_HUMAN (2-965): 2.9e-165: 512: 18.03
+	Hs
		944192 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		TIE2_HUMAN (87-859): 1.29e-155: 491: 22.06
+	Hs
		435610 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		IGF1R_HUMAN (318-859): 5.21e-138: 449: 28.34
+	Hs
		944196 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		RON_HUMAN (535-861): 1.17e-59: 225: 37.95
+	Hs
		337429 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		ABL1_HUMAN (582-859): 9.16e-60: 224: 43.89
+	Hs
		713782 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		RYK_HUMAN (572-850): 9.94e-61: 220: 40.28
+	Hs
		445842 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		ROS1_HUMAN (564-883): 3.94e-57: 218: 40.12
+	Hs
		601494 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		FGFR2_HUMAN (1-295): 4.46e-53: 201: 14.21
+	Hs
		609246 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		FGFR3_HUMAN (2-295): 1.33e-41: 166: 13.41
+	Hs
		944199 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		TYRO3_HUMAN (4-393): 7.12e-20: 97.6: 12.62
+	Hs
		674388 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		UFO_HUMAN (16-405): 5.47e-13: 75.2: 10.75
+	Hs
		872435 ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42		EPHA5_HUMAN (29-967): 0: 639: 17.50
+	Hs
		445886 TRRAP_HUMAN (2754-4128): 0: 828: 15.88		ROS1_HUMAN (564-883): 3.94e-57: 218: 40.12
+	Hs
		600653 SMG1_HUMAN (3179-4115): 6.6e-124: 444: 16.20		EPHA1_HUMAN (2-965): 2.9e-165: 512: 18.03
+	Hs
		337382 MTOR_HUMAN (2776-4127): 0: 695: 15.99		ABL1_HUMAN (582-859): 9.16e-60: 224: 43.89
+	Hs
		337460 ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42		ABL1_HUMAN (582-859): 9.16e-60: 224: 43.89
+	Hs
		337465 ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28		ABL1_HUMAN (582-859): 9.16e-60: 224: 43.89