Protein: ZN263
Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12)

Gene: ZN263, ZNF263
Organism: Homo sapiens
Interactions: 146
UniProt ID: O14978

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

171856

SCND1
SCAN domain-containing protein 1

6

20

High-throughput

0.951

High

171933

ZN446
Zinc finger protein 446

3

20

High-throughput

0.875

High

171832

ZNF24
Zinc finger protein 24

3

20

High-throughput

0.861

High

171833

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

19

High-throughput

0.861

High

171903

ZN397
Zinc finger protein 397

3

20

High-throughput

0.861

High

171857

ZN445
Zinc finger protein 445

2

10

High-throughput

0.811

High

171883

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

2

18

High-throughput

0.811

High

171896

ZN444
Zinc finger protein 444

2

20

High-throughput

0.811

High

171942

ZN232
Zinc finger protein 232

2

20

High-throughput

0.811

High

171827

ZSC22
Zinc finger and SCAN domain-containing protein 22

2

19

High-throughput

0.783

High

171850

ZN165
Zinc finger protein 165

2

19

High-throughput

0.783

High

171848

CLK2
Dual specificity protein kinase CLK2

1

3

High-throughput

0.740

High

171849

CLK3
Dual specificity protein kinase CLK3

1

3

High-throughput

0.740

High

171906

TRI41
E3 ubiquitin-protein ligase TRIM41

5

20

High-throughput

0.722

High

171902

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

20

High-throughput

0.698

High

171887

ZSC23
Zinc finger and SCAN domain-containing protein 23

1

20

High-throughput

0.691

High

171897

ZN687
Zinc finger protein 687

1

7

High-throughput

0.691

High

171932

GPT2L
G patch domain-containing protein 2-like

3

0

High-throughput

0.646

High

171120

MYPT1
Protein phosphatase 1 regulatory subunit 12A

2

20

High-throughput

0.628

High

171818

ANR17
Ankyrin repeat domain-containing protein 17

2

4

High-throughput

0.628

High

171821

TRI37
E3 ubiquitin-protein ligase TRIM37

2

16

High-throughput

0.628

High

171822

ZMYM6
Zinc finger MYM-type protein 6

2

7

High-throughput

0.628

High

171826

CENPB
Major centromere autoantigen B

2

8

High-throughput

0.628

High

171839

NKTR
NK-tumor recognition protein

2

2

High-throughput

0.628

High

171860

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

3

High-throughput

0.628

High

171872

NFX1
Transcriptional repressor NF-X1

2

20

High-throughput

0.628

High

171890

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

3

High-throughput

0.628

High

171891

FBX11
F-box only protein 11

2

4

High-throughput

0.628

High

171899

ASCC3
Activating signal cointegrator 1 complex subunit 3

2

1

High-throughput

0.628

High

171904

COP1
E3 ubiquitin-protein ligase COP1

2

5

High-throughput

0.628

High

171910

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

5

High-throughput

0.628

High

171913

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

1

High-throughput

0.628

High

171917

LENG8
Leukocyte receptor cluster member 8

2

1

High-throughput

0.628

High

171924

VPS11
Vacuolar protein sorting-associated protein 11 homolog

2

1

High-throughput

0.628

High

171929

TOPRS
E3 ubiquitin-protein ligase Topors

2

2

High-throughput

0.628

High

171934

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

2

2

High-throughput

0.628

High

171936

ZMYM2
Zinc finger MYM-type protein 2

2

7

High-throughput

0.628

High

171948

DCAF1
DDB1- and CUL4-associated factor 1

2

4

High-throughput

0.628

High

171950

ARI1
E3 ubiquitin-protein ligase ARIH1

2

15

High-throughput

0.628

High

171838

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.618

High

171885

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.618

High

171905

LNX1
E3 ubiquitin-protein ligase LNX

2

5

High-throughput

0.606

High

171912

ARK2N
Protein ARK2N

2

0

High-throughput

0.602

High

171930

RAD18
E3 ubiquitin-protein ligase RAD18

2

0

High-throughput

0.602

High

171941

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.582

High

171816

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

1

High-throughput

0.574

High

171820

MTCL2
Microtubule cross-linking factor 2

2

5

High-throughput

0.574

High

171862

RT35
Small ribosomal subunit protein mS35

2

1

High-throughput

0.574

High

171876

SCRIB
Protein scribble homolog

2

3

High-throughput

0.574

High

171879

CUL7
Cullin-7

2

9

High-throughput

0.574

High

171886

KIF7
Kinesin-like protein KIF7

2

4

High-throughput

0.574

High

171893

ANKH1
Ankyrin repeat and KH domain-containing protein 1

2

4

High-throughput

0.574

High

171898

LTBP4
Latent-transforming growth factor beta-binding protein 4

2

20

High-throughput

0.574

High

171900

FBXW8
F-box/WD repeat-containing protein 8

2

5

High-throughput

0.574

High

171901

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

2

4

High-throughput

0.574

High

171914

RT24
Small ribosomal subunit protein uS3m

2

2

High-throughput

0.574

High

171915

SAHH3
Adenosylhomocysteinase 3

2

1

High-throughput

0.574

High

171916

VPS39
Vam6/Vps39-like protein

2

2

High-throughput

0.574

High

171918

PEO1
Twinkle mtDNA helicase

2

1

High-throughput

0.574

High

171947

MTCL1
Microtubule cross-linking factor 1

2

2

High-throughput

0.574

High

171817

PEPL
Periplakin

2

5

High-throughput

0.553

High

171911

JKIP2
Janus kinase and microtubule-interacting protein 2

2

2

High-throughput

0.553

High

159419

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

6

High-throughput

0.541

High

171926

PKHF2
Pleckstrin homology domain-containing family F member 2

1

8

High-throughput

0.541

High

171951

NDK7
Nucleoside diphosphate kinase homolog 7

1

1

High-throughput

0.541

High

171813

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.536

High

171867

NOTC2
Neurogenic locus notch homolog protein 2

1

20

High-throughput

0.536

High

171949

TCAF1
TRPM8 channel-associated factor 1

1

1

High-throughput

0.523

High

171823

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

20

High-throughput

0.494

High

171858

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

3

High-throughput

0.494

High

171824

FRIL
Ferritin light chain

1

1

High-throughput

0.489

High

171863

RT05
Small ribosomal subunit protein uS5m

1

2

High-throughput

0.489

High

171878

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

20

High-throughput

0.489

High

171920

CEP89
Centrosomal protein of 89 kDa

1

4

High-throughput

0.489

High

171945

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.489

High

142712

NFIB
Nuclear factor 1 B-type

1

7

Small-scale

0.479

High

171819

MTA2
Metastasis-associated protein MTA2

1

2

Small-scale

0.479

High

171830

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

171831

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

171834

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

Small-scale

0.479

High

171835

SFPQ
Splicing factor, proline- and glutamine-rich

1

4

Small-scale

0.479

High

171836

BRD2
Bromodomain-containing protein 2

1

3

Small-scale

0.479

High

171837

DNMT1
DNA

1

1

Small-scale

0.479

High

171841

RBMX
RNA-binding motif protein, X chromosome

1

2

Small-scale

0.479

High

171845

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.479

High

171846

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.479

High

171853

MECP2
Methyl-CpG-binding protein 2

1

2

Small-scale

0.479

High

171854

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.479

High

171859

WDR5
WD repeat-containing protein 5

1

1

Small-scale

0.479

High

171861

RNF4
E3 ubiquitin-protein ligase RNF4

1

15

High-throughput

0.479

High

171865

PURA
Transcriptional activator protein Pur-alpha

1

12

Small-scale

0.479

High

171868

RBBP4
Histone-binding protein RBBP4

1

2

Small-scale

0.479

High

171869

TRI26
Tripartite motif-containing protein 26

1

19

Small-scale

0.479

High

171870

ILF2
Interleukin enhancer-binding factor 2

1

1

Small-scale

0.479

High

171871

ILF3
Interleukin enhancer-binding factor 3

1

5

Small-scale

0.479

High

171873

CBX3
Chromobox protein homolog 3

1

20

Small-scale

0.479

High

171874

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.479

High

171875

SAFB2
Scaffold attachment factor B2

1

2

Small-scale

0.479

High

171877

HLTF
Helicase-like transcription factor

1

3

Small-scale

0.479

High

171880

SETB1
Histone-lysine N-methyltransferase SETDB1

1

7

Small-scale

0.479

High

171881

BRD3
Bromodomain-containing protein 3

1

2

Small-scale

0.479

High

171882

NONO
Non-POU domain-containing octamer-binding protein

1

6

Small-scale

0.479

High

171884

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

Small-scale

0.479

High

171894

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

3

Small-scale

0.479

High

171907

PSPC1
Paraspeckle component 1

1

6

Small-scale

0.479

High

171908

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.479

High

171909

RAD50
DNA repair protein RAD50

1

4

Small-scale

0.479

High

171919

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

171921

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

4

Small-scale

0.479

High

171925

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

2

Small-scale

0.479

High

171928

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

4

Small-scale

0.479

High

171931

SLTM
SAFB-like transcription modulator

1

4

Small-scale

0.479

High

171937

BAZ1B
Tyrosine-protein kinase BAZ1B

1

17

Small-scale

0.479

High

134478

SAP18
Histone deacetylase complex subunit SAP18

1

0

Small-scale

0.458

High

141206

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

171828

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

171829

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.458

High

171840

RFC1
Replication factor C subunit 1

1

0

Small-scale

0.458

High

171842

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

171843

RFC3
Replication factor C subunit 3

1

0

Small-scale

0.458

High

171847

MCM2
DNA replication licensing factor MCM2

1

0

Small-scale

0.458

High

171851

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

171855

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.458

High

171864

ERH
Enhancer of rudimentary homolog

1

0

Small-scale

0.458

High

171866

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

Small-scale

0.458

High

171892

PHF6
PHD finger protein 6

1

0

Small-scale

0.458

High

171922

CDC5L
Cell division cycle 5-like protein

1

0

Small-scale

0.458

High

171923

SRRT
Serrate RNA effector molecule homolog

1

0

Small-scale

0.458

High

171939

PARP4
Protein mono-ADP-ribosyltransferase PARP4

1

0

Small-scale

0.458

High

171940

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

171943

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

171944

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.458

High

171953

DNM3A
DNA

1

0

Small-scale

0.458

High

171825

FRIH
Ferritin heavy chain

1

1

High-throughput

0.445

High

171814

RRP8
Ribosomal RNA-processing protein 8

1

2

Small-scale

0.437

High

171852

EMD
Emerin

1

1

High-throughput

0.437

High

171888

GLYR1
Cytokine-like nuclear factor N-PAC

1

2

Small-scale

0.437

High

171946

CHTOP
Chromatin target of PRMT1 protein

1

1

Small-scale

0.437

High

171927

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.417

High

171895

THNS1
Threonine synthase-like 1

2

0

High-throughput

0.328

High

171938

KLH21
Kelch-like protein 21

2

0

High-throughput

0.328

High

171935

SPG21
Maspardin

1

0

High-throughput

0.282

High

171844

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.279

Low

171889

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.279

Low

171952

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.279

Low

171815

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025