HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: SRRM1 (Q8IYB3)
Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)
Gene: SRRM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33961781, 16159877, 10809668
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0048024 - regulation of mRNA splicing, via spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 904
+	Hs
		1084330 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRRM1_HUMAN (1-904): 7.55e-73: 259: 100.00
+	Hs
		703409 CSTF2_HUMAN (10-110): 1.87e-25: 103: 25.47		SRRM1_HUMAN (1-904): 7.55e-73: 259: 100.00
+	Hs
		992840 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRRM1_HUMAN (1-904): 7.55e-73: 259: 100.00
+	Hs
		1028727 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		SRRM1_HUMAN (1-904): 7.55e-73: 259: 100.00
+	At
		1226401 SR30_ARATH (5-90): 4.74e-26: 101: 44.32		Q8L7W3_ARATH (1-882): 1.55e-49: 191: 23.98
+	Hs
		257590 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		ANR17_HUMAN (107-903): 3.38e-30: 131: 13.10
+	Hs
		992772 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		1084451 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		132307 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		CAC1A_HUMAN (94-637): 2.17e-09: 63.6: 14.46
+	Hs
		952179 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		992995 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		1031402 PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09		ATX2L_HUMAN (104-788): 2.79e-11: 69.6: 10.35
+	Hs
		1028876 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		267100 SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		516606 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		ATX2L_HUMAN (104-788): 2.79e-11: 69.6: 10.35
+	Hs
		1028547 SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79		MDC1_HUMAN (204-903): 7.29e-13: 75: 9.61
+	Hs
		516595 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		965152 PABP3_HUMAN (1-91): 6.48e-19: 84.6: 23.71		ANK2_HUMAN (110-849): 7.77e-11: 68.6: 14.10
+	Hs
		516749 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		SRRM2_HUMAN (189-896): 4.93e-09: 62.6: 13.28
+	Hs
		1200914 RBM4_HUMAN (11-88): 3.45e-18: 81.9: 28.21		Q86V38_HUMAN (108-815): 1.29e-09: 64.2: 10.99