Protein: PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]

Gene: PPP6, PPP6C
Organism: Homo sapiens
Interactions: 223
UniProt ID: O00743

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

143619

IGBP1
Immunoglobulin-binding protein 1

11

20

Small-scale

0.982

High

143509

TIPRL
TIP41-like protein

5

7

Small-scale

0.927

High

143643

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

12

9

Small-scale

0.759

High

143715

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

10

9

Small-scale

0.758

High

143508

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

10

12

Small-scale

0.758

High

143502

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

8

3

Small-scale

0.754

High

143609

RHOA
Transforming protein RhoA

2

6

High-throughput

0.737

High

143621

PRKDC
DNA-dependent protein kinase catalytic subunit

5

10

Small-scale

0.721

High

143499

AURKA
Aurora kinase A

5

18

High-throughput

0.711

High

143620

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.699

High

143677

ARHG2
Rho guanine nucleotide exchange factor 2

4

5

Small-scale

0.697

High

143597

PLK1
Serine/threonine-protein kinase PLK1

4

15

High-throughput

0.694

High

143498

ML12B
Myosin regulatory light chain 12B

1

3

High-throughput

0.691

High

143664

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

7

3

Small-scale

0.684

High

143665

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

6

3

Small-scale

0.676

High

143504

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

7

Small-scale

0.667

High

143679

AURKB
Aurora kinase B

3

19

High-throughput

0.640

High

143536

HSP7C
Heat shock cognate 71 kDa protein

3

10

High-throughput

0.633

High

143701

MOB1A
MOB kinase activator 1A

2

6

High-throughput

0.621

High

143518

RASK
GTPase KRas

1

3

High-throughput

0.618

High

143523

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.618

High

143528

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.618

High

143531

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.618

High

143600

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.618

High

143605

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

13

High-throughput

0.618

High

143610

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

14

High-throughput

0.618

High

143702

PIDD1
p53-induced death domain-containing protein 1

1

14

Small-scale

0.618

High

143517

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.611

High

143625

VAC14
Protein VAC14 homolog

2

6

High-throughput

0.606

High

143606

RAB10
Ras-related protein Rab-10

1

0

High-throughput

0.586

High

143575

BRCA1
Breast cancer type 1 susceptibility protein

2

9

High-throughput

0.584

High

143644

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.575

High

143632

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.573

High

143553

RASA1
Ras GTPase-activating protein 1

2

6

High-throughput

0.571

High

143596

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

1

High-throughput

0.571

High

143653

RHG22
Rho GTPase-activating protein 22

2

5

High-throughput

0.571

High

143675

ESR2
Estrogen receptor beta

2

14

High-throughput

0.571

High

143676

BAD
Bcl2-associated agonist of cell death

2

2

High-throughput

0.571

High

143650

MOB1B
MOB kinase activator 1B

1

6

High-throughput

0.554

High

143686

RB40C
Ras-related protein Rab-40C

1

1

Small-scale

0.553

High

143552

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.547

High

143667

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

Small-scale

0.537

High

143507

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

15

High-throughput

0.536

High

143533

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

143534

ARAF
Serine/threonine-protein kinase A-Raf

1

16

High-throughput

0.536

High

143537

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

143538

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

2

High-throughput

0.536

High

143548

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.536

High

143554

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

2

High-throughput

0.536

High

143570

CLIP1
CAP-Gly domain-containing linker protein 1

1

10

High-throughput

0.536

High

143577

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

143580

HD
Huntingtin

1

3

High-throughput

0.536

High

143584

UTRN
Utrophin

1

3

High-throughput

0.536

High

143585

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

143589

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

143593

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

143595

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

143599

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

9

High-throughput

0.536

High

143617

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.536

High

143628

ILK
Scaffold protein ILK

1

3

High-throughput

0.536

High

143658

DDX60
Probable ATP-dependent RNA helicase DDX60

1

6

High-throughput

0.536

High

143690

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

143692

TBB6
Tubulin beta-6 chain

1

5

High-throughput

0.536

High

143706

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

9

High-throughput

0.536

High

143640

RCN1
Reticulocalbin-1

1

0

High-throughput

0.517

High

134199

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

143526

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.513

High

143656

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

143660

TRM2A
tRNA

1

0

High-throughput

0.513

High

143697

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

143629

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.506

High

143529

SP1
Transcription factor Sp1

1

9

High-throughput

0.500

High

143669

SP7
Transcription factor Sp7

1

8

High-throughput

0.500

High

143639

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

127739

IKBE
NF-kappa-B inhibitor epsilon

1

11

High-throughput

0.479

High

129906

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.479

High

143501

XPO1
Exportin-1

1

8

High-throughput

0.479

High

143506

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.479

High

143510

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

143512

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

143513

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

143514

IPO7
Importin-7

1

4

High-throughput

0.479

High

143515

RIGI
Antiviral innate immune response receptor RIG-I

1

10

High-throughput

0.479

High

143516

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.479

High

143520

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.479

High

143522

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

143525

LA
Lupus La protein

1

10

High-throughput

0.479

High

143535

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.479

High

143539

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

143540

XRCC5
X-ray repair cross-complementing protein 5

1

2

High-throughput

0.479

High

143542

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

143544

BRAF
Serine/threonine-protein kinase B-raf

1

16

High-throughput

0.479

High

143545

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

143547

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

143550

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.479

High

143551

NUCL
Nucleolin

1

7

High-throughput

0.479

High

143555

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.479

High

143556

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

143557

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

143558

PSA2
Proteasome subunit alpha type-2

1

6

High-throughput

0.479

High

143559

PSA4
Proteasome subunit alpha type-4

1

5

High-throughput

0.479

High

143560

SYVC
Valine--tRNA ligase

1

2

High-throughput

0.479

High

143561

EF1G
Elongation factor 1-gamma

1

4

High-throughput

0.479

High

143562

1433T
14-3-3 protein theta

1

14

High-throughput

0.479

High

143563

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

143564

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

143565

PYR1
Multifunctional protein CAD

1

6

High-throughput

0.479

High

143567

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

143568

PSB5
Proteasome subunit beta type-5

1

6

High-throughput

0.479

High

143569

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.479

High

143572

NOS2
Nitric oxide synthase, inducible

1

3

High-throughput

0.479

High

143573

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

143574

PRS7
26S proteasome regulatory subunit 7

1

3

High-throughput

0.479

High

143576

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

143578

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

143579

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

143581

PRS6B
26S proteasome regulatory subunit 6B

1

5

High-throughput

0.479

High

143582

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.479

High

143583

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

143586

KC1D
Casein kinase I isoform delta

1

10

Small-scale

0.479

High

143587

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

143588

FAS
Fatty acid synthase

1

2

High-throughput

0.479

High

143590

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

143591

GUAA
GMP synthase [glutamine-hydrolyzing]

1

3

High-throughput

0.479

High

143592

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.479

High

143598

COPA
Coatomer subunit alpha

1

2

High-throughput

0.479

High

143601

XPO2
Exportin-2

1

8

High-throughput

0.479

High

143602

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

143604

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.479

High

143607

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

143608

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.479

High

143611

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

143612

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.479

High

143613

PRS10
26S proteasome regulatory subunit 10B

1

4

High-throughput

0.479

High

143614

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

143615

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

143616

AP2B1
AP-2 complex subunit beta

1

1

High-throughput

0.479

High

143618

TBA4A
Tubulin alpha-4A chain

1

7

High-throughput

0.479

High

143623

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

143624

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

High-throughput

0.479

High

143626

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

143627

TIF1B
Transcription intermediary factor 1-beta

1

10

High-throughput

0.479

High

143630

SQSTM
Sequestosome-1

1

5

High-throughput

0.479

High

143631

CUL3
Cullin-3

1

11

High-throughput

0.479

High

143633

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.479

High

143634

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

143636

LASP1
LIM and SH3 domain protein 1

1

1

High-throughput

0.479

High

143637

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

143638

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

143641

PCBP1
Poly(rC)-binding protein 1

1

5

High-throughput

0.479

High

143649

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

143652

MAVS
Mitochondrial antiviral-signaling protein

1

7

High-throughput

0.479

High

143654

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

143655

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.479

High

143659

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.479

High

143661

STK40
Serine/threonine-protein kinase 40

1

15

Small-scale

0.479

High

143668

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.479

High

143670

ASB11
Ankyrin repeat and SOCS box protein 11

1

7

High-throughput

0.479

High

143671

DDX1
ATP-dependent RNA helicase DDX1

1

5

High-throughput

0.479

High

143672

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

143673

HS105
Heat shock protein 105 kDa

1

16

High-throughput

0.479

High

143674

GCN1
Stalled ribosome sensor GCN1

1

18

High-throughput

0.479

High

143678

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.479

High

143680

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

143682

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

143683

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

143684

FMNL2
Formin-like protein 2

1

3

High-throughput

0.479

High

143685

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

143688

RING2
E3 ubiquitin-protein ligase RING2

1

11

High-throughput

0.479

High

143689

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.479

High

143691

PCGF1
Polycomb group RING finger protein 1

1

7

High-throughput

0.479

High

143693

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.479

High

143695

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

7

High-throughput

0.479

High

143699

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

143700

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

143703

NMRL1
NmrA-like family domain-containing protein 1

1

4

High-throughput

0.479

High

143704

MYO10
Unconventional myosin-X

1

12

Small-scale

0.479

High

143707

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

143709

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

143710

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

4

Small-scale

0.479

High

143712

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

143713

TBK1
Serine/threonine-protein kinase TBK1

1

20

High-throughput

0.479

High

143714

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

143716

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

143503

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.458

High

143511

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

0

High-throughput

0.458

High

143527

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.458

High

143532

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

143543

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

143549

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.458

High

143571

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

143594

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

143663

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

143681

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

143687

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.458

High

143694

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

143696

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

143705

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

143708

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

143711

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

143500

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

143521

HG2A
HLA class II histocompatibility antigen gamma chain

1

2

High-throughput

0.445

High

143541

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

143603

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.445

High

143645

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.445

High

143519

TNFA
Tumor necrosis factor

1

2

Small-scale

0.437

High

143524

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.437

High

143530

IGF1R
Insulin-like growth factor 1 receptor

1

5

High-throughput

0.437

High

143546

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.437

High

143622

ZXDA
Zinc finger X-linked protein ZXDA

1

5

Small-scale

0.437

High

143651

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

143662

FBXL6
F-box/LRR-repeat protein 6

1

7

High-throughput

0.437

High

143698

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.437

High

143505

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

104056

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

143647

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.407

High

143657

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

1

High-throughput

0.407

High

143666

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

143566

CALX
Calnexin

1

0

High-throughput

0.249

Low

143635

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.249

Low

143642

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

143646

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

143648

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025