Protein: TRI42
Tripartite motif-containing protein 42

Gene: TRI42, TRIM42
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q8IWZ5

Gene Ontology (top 5):
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1165286

LONF1
LON peptidase N-terminal domain and RING finger protein 1

3

19

High-throughput

0.871

High

1311446

LNX1
E3 ubiquitin-protein ligase LNX

2

19

High-throughput

0.783

High

291835

STK16
Serine/threonine-protein kinase 16

3

18

High-throughput

0.779

High

572058

TRI27
Zinc finger protein RFP

1

19

High-throughput

0.740

High

783321

TRI23
E3 ubiquitin-protein ligase TRIM23

1

20

High-throughput

0.740

High

1090772

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.740

High

1311482

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

19

High-throughput

0.740

High

1277303

NT2NA
Notch homolog 2 N-terminal-like protein A

2

12

High-throughput

0.731

High

351567

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

15

High-throughput

0.700

High

654529

FBLN1
Fibulin-1

2

20

High-throughput

0.700

High

1119752

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

20

High-throughput

0.700

High

1198248

FND3B
Fibronectin type III domain-containing protein 3B

2

18

High-throughput

0.700

High

1286367

NEK8
Serine/threonine-protein kinase Nek8

2

20

High-throughput

0.700

High

1290357

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

2

20

High-throughput

0.700

High

1311449

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

10

High-throughput

0.700

High

1311435

TRI42
Tripartite motif-containing protein 42

1

18

High-throughput

0.698

High

1271368

KCTD9
BTB/POZ domain-containing protein KCTD9

3

16

High-throughput

0.675

High

1311439

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

4

High-throughput

0.662

High

885328

HXA1
Homeobox protein Hox-A1

3

20

High-throughput

0.616

High

1180791

KLH38
Kelch-like protein 38

3

12

High-throughput

0.616

High

1039784

CREB5
Cyclic AMP-responsive element-binding protein 5

2

8

High-throughput

0.615

High

675574

TYY1
Transcriptional repressor protein YY1

2

20

High-throughput

0.606

High

1311456

ZN414
Zinc finger protein 414

2

1

High-throughput

0.606

High

1311488

ZN330
Zinc finger protein 330

2

1

High-throughput

0.606

High

894885

EMD
Emerin

2

2

High-throughput

0.597

High

517055

NT2NC
Notch homolog 2 N-terminal-like protein C

1

14

High-throughput

0.594

High

893994

MEOX2
Homeobox protein MOX-2

2

18

High-throughput

0.578

High

691222

1433T
14-3-3 protein theta

2

20

High-throughput

0.573

High

180548

PLS1
Phospholipid scramblase 1

1

7

High-throughput

0.573

High

466682

GLI1
Zinc finger protein GLI1

1

20

High-throughput

0.573

High

1055240

MTG8
Protein CBFA2T1

1

6

High-throughput

0.573

High

1093871

TRAF1
TNF receptor-associated factor 1

1

17

High-throughput

0.573

High

1311451

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

2

High-throughput

0.573

High

1311461

SCNM1
Sodium channel modifier 1

1

4

High-throughput

0.573

High

1311483

IKZF3
Zinc finger protein Aiolos

1

20

High-throughput

0.573

High

1311486

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

20

High-throughput

0.573

High

71129

VGLL3
Transcription cofactor vestigial-like protein 3

2

1

High-throughput

0.553

High

74133

VWC2L
von Willebrand factor C domain-containing protein 2-like

2

3

High-throughput

0.553

High

163456

MEIS2
Homeobox protein Meis2

2

6

High-throughput

0.553

High

225057

TLX3
T-cell leukemia homeobox protein 3

2

17

High-throughput

0.553

High

225635

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

6

High-throughput

0.553

High

246252

MABP1
Mitogen-activated protein kinase-binding protein 1

2

20

High-throughput

0.553

High

270511

SLIT1
Slit homolog 1 protein

2

12

High-throughput

0.553

High

277120

PROP1
Homeobox protein prophet of Pit-1

2

10

High-throughput

0.553

High

300413

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.553

High

715927

AQP1
Aquaporin-1

2

4

High-throughput

0.553

High

725090

HXC8
Homeobox protein Hox-C8

2

19

High-throughput

0.553

High

733184

OTX1
Homeobox protein OTX1

2

15

High-throughput

0.553

High

948354

KR122
Keratin-associated protein 12-2

2

12

High-throughput

0.553

High

950573

KR108
Keratin-associated protein 10-8

2

14

High-throughput

0.553

High

1086977

PO4F2
POU domain, class 4, transcription factor 2

2

13

High-throughput

0.553

High

1212941

LCE3E
Late cornified envelope protein 3E

2

4

High-throughput

0.553

High

1213774

KPRP
Keratinocyte proline-rich protein

2

1

High-throughput

0.553

High

1213909

LCE1C
Late cornified envelope protein 1C

2

2

High-throughput

0.553

High

1213993

LCE1E
Late cornified envelope protein 1E

2

1

High-throughput

0.553

High

1214315

LCE1B
Late cornified envelope protein 1B

2

1

High-throughput

0.553

High

1215048

LCE3A
Late cornified envelope protein 3A

2

1

High-throughput

0.553

High

1215149

LCE2A
Late cornified envelope protein 2A

2

1

High-throughput

0.553

High

1215182

LCE2C
Late cornified envelope protein 2C

2

2

High-throughput

0.553

High

1215222

LCE2D
Late cornified envelope protein 2D

2

2

High-throughput

0.553

High

1235769

KR511
Keratin-associated protein 5-11

2

12

High-throughput

0.553

High

1235794

KRA57
Keratin-associated protein 5-7

2

12

High-throughput

0.553

High

1276203

ATG9A
Autophagy-related protein 9A

2

2

High-throughput

0.553

High

1295058

F90A1
Protein FAM90A1

2

7

High-throughput

0.553

High

1311443

CTSR1
Cation channel sperm-associated protein 1

2

9

High-throughput

0.553

High

1311447

CERK1
Ceramide kinase

2

2

High-throughput

0.553

High

1311450

SMRC1
SWI/SNF complex subunit SMARCC1

2

15

High-throughput

0.553

High

1311455

CC120
Coiled-coil domain-containing protein 120

2

6

High-throughput

0.553

High

1311463

LCE3D
Late cornified envelope protein 3D

2

4

High-throughput

0.553

High

1311464

KRA93
Keratin-associated protein 9-3

2

12

High-throughput

0.553

High

1311465

KRA45
Keratin-associated protein 4-5

2

12

High-throughput

0.553

High

1311466

KRA44
Keratin-associated protein 4-4

2

12

High-throughput

0.553

High

1311470

BACH2
Transcription regulator protein BACH2

2

20

High-throughput

0.553

High

1311471

YIPF3
Protein YIPF3

2

1

High-throughput

0.553

High

1311473

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

5

High-throughput

0.553

High

1311474

CHRD
Chordin

2

12

High-throughput

0.553

High

1311475

F124B
Protein FAM124B

2

2

High-throughput

0.553

High

1311478

PLS4
Phospholipid scramblase 4

2

1

High-throughput

0.553

High

1311479

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

2

4

High-throughput

0.553

High

1311484

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

2

2

High-throughput

0.553

High

1311487

R3HD2
R3H domain-containing protein 2

2

20

High-throughput

0.553

High

1311489

TCAF1
TRPM8 channel-associated factor 1

2

3

High-throughput

0.553

High

128452

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

2

High-throughput

0.523

High

300187

GLRX3
Glutaredoxin-3

1

20

High-throughput

0.523

High

618068

K1C15
Keratin, type I cytoskeletal 15

1

20

High-throughput

0.523

High

680939

PSA1
Proteasome subunit alpha type-1

1

16

High-throughput

0.523

High

845453

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

2

High-throughput

0.523

High

935552

MFAP1
Microfibrillar-associated protein 1

1

6

High-throughput

0.523

High

950321

KR107
Keratin-associated protein 10-7

1

12

High-throughput

0.523

High

950824

KR109
Keratin-associated protein 10-9

1

14

High-throughput

0.523

High

1063410

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.523

High

1205867

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

20

High-throughput

0.523

High

1206400

EFHC2
EF-hand domain-containing family member C2

1

4

High-throughput

0.523

High

1218929

TASO2
Protein TASOR 2

1

20

High-throughput

0.523

High

1230122

K1C40
Keratin, type I cytoskeletal 40

1

20

High-throughput

0.523

High

1250257

ATL4
ADAMTS-like protein 4

1

7

High-throughput

0.523

High

1309097

GLCTK
Glycerate kinase

1

1

High-throughput

0.523

High

1311436

IHO1
Interactor of HORMAD1 protein 1

1

1

High-throughput

0.523

High

1311442

PNMA1
Paraneoplastic antigen Ma1

1

9

High-throughput

0.523

High

1311444

VP37A
Vacuolar protein sorting-associated protein 37A

1

2

High-throughput

0.523

High

1311445

CEP70
Centrosomal protein of 70 kDa

1

1

High-throughput

0.523

High

1311452

MGN2
Protein mago nashi homolog 2

1

4

High-throughput

0.523

High

1311453

ARRD3
Arrestin domain-containing protein 3

1

11

High-throughput

0.523

High

1311459

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.523

High

1311460

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

2

High-throughput

0.523

High

1311462

BEX2
Protein BEX2

1

4

High-throughput

0.523

High

1311467

KRA42
Keratin-associated protein 4-2

1

12

High-throughput

0.523

High

1311472

CARD9
Caspase recruitment domain-containing protein 9

1

20

High-throughput

0.523

High

1311476

ARMC7
Armadillo repeat-containing protein 7

1

1

High-throughput

0.523

High

1311480

AIRIM
AFG2-interacting ribosome maturation factor

1

1

High-throughput

0.523

High

1311481

RCOR3
REST corepressor 3

1

12

High-throughput

0.523

High

1311485

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.523

High

1311477

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

12

High-throughput

0.494

High

2811

A0A0C3SFZ9
FCH and mu domain containing endocytic adaptor 1

1

11

High-throughput

0.470

High

49900

A1A4E9
Keratin 13

1

20

High-throughput

0.470

High

59960

A2BDE7
PHLDA1 protein

1

7

High-throughput

0.470

High

950093

KR105
Keratin-associated protein 10-5

1

14

High-throughput

0.470

High

1232444

Q6FHY5
MEOX2 protein

1

20

High-throughput

0.470

High

1279616

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

14

High-throughput

0.470

High

1289407

Q86UY0
Thioredoxin domain-containing protein 5

1

20

High-throughput

0.470

High

1311469

KRA24
Keratin-associated protein 2-4

1

11

High-throughput

0.470

High

967843

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

14

Small-scale

0.457

High

570

NBPFJ
NBPF family member NBPF19

1

19

High-throughput

0.439

High

155680

FCHO1
F-BAR domain only protein 1

1

10

High-throughput

0.439

High

181140

AXIN1
Axin-1

1

10

High-throughput

0.439

High

505351

KRA23
Keratin-associated protein 2-3

1

11

High-throughput

0.439

High

566287

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.439

High

949741

KR101
Keratin-associated protein 10-1

1

13

High-throughput

0.439

High

949928

KR103
Keratin-associated protein 10-3

1

14

High-throughput

0.439

High

1131970

MVP
Major vault protein

1

6

High-throughput

0.439

High

1191377

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

1

High-throughput

0.439

High

1277849

NUFP2
FMR1-interacting protein NUFIP2

1

4

High-throughput

0.439

High

1311438

CCD33
Coiled-coil domain-containing protein 33

1

2

High-throughput

0.439

High

1311441

TXND5
Thioredoxin domain-containing protein 5

1

20

High-throughput

0.439

High

1311448

PHLA1
Pleckstrin homology-like domain family A member 1

1

7

High-throughput

0.439

High

3351

A0A0S2Z4M1
Axin-1

1

10

High-throughput

0.417

High

1311491

X5D7R7
Major vault protein

1

6

High-throughput

0.417

High

70337

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

159080

LCE2B
Late cornified envelope protein 2B

2

0

High-throughput

0.316

High

892224

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.316

High

1212909

LCE3C
Late cornified envelope protein 3C

2

0

High-throughput

0.316

High

1213953

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.316

High

1214038

LCE1F
Late cornified envelope protein 1F

2

0

High-throughput

0.316

High

1214272

LCE1A
Late cornified envelope protein 1A

2

0

High-throughput

0.316

High

1215110

LCE4A
Late cornified envelope protein 4A

2

0

High-throughput

0.316

High

1215941

LCE5A
Late cornified envelope protein 5A

2

0

High-throughput

0.316

High

1280261

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

1287176

T150A
Transmembrane protein 150A

2

0

High-throughput

0.316

High

1311437

CCD24
Coiled-coil domain-containing protein 24

2

0

High-throughput

0.316

High

1311457

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1311458

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.316

High

1311490

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

0

High-throughput

0.316

High

1244041

KR261
Keratin-associated protein 26-1

1

0

High-throughput

0.299

High

1311440

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.299

High

1311454

CDA7L
Cell division cycle-associated 7-like protein

1

0

High-throughput

0.299

High

1311468

KRA32
Keratin-associated protein 3-2

1

0

High-throughput

0.299

High

515641

TPC2A
Trafficking protein particle complex subunit 2

1

0

High-throughput

0.268

Low

1235834

KRA56
Keratin-associated protein 5-6

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025