HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: CBX2 (Q14781)
Chromobox protein homolog 2
Gene: CBX2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	32395866, 18927235, 36089195
Identification Methods	affinity chromatography technology, protein complementation assay, proximity labelling technology, bimolecular fluorescence complementation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 532
+	Hs
		934768 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00
+	Mm
		675496 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84
+	Mm
		223226 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		CBX4_MOUSE (3-522): 1.1e-116: 357: 22.28
+	Hs
		123231 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Hs
		935387 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CDYL_HUMAN (2-297): 1.28e-60: 211: 21.63
+	Hs
		935156 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		MPP8_HUMAN (7-397): 6.88e-47: 177: 17.54
+	Hs
		934987 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CDYL2_HUMAN (10-297): 9.15e-48: 175: 17.81
+	Mm
		952770 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		CBX6_MOUSE (3-242): 3.88e-43: 160: 31.12
+	Hs
		316000 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Hs
		934657 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX1_HUMAN (18-153): 1.81e-38: 141: 22.79
+	Mm
		935445 H31_MOUSE (1-136): 3.08e-60: 183: 96.32		CBX1_MOUSE (18-153): 1.81e-38: 141: 22.79
+	Hs
		935259 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		934721 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Mm
		952771 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		Q9DCC5_MOUSE (9-152): 1.29e-37: 138: 21.53
+	Hs
		327837 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX7_HUMAN (3-210): 1.4e-35: 135: 27.98
+	Hs
		800341 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBX5_HUMAN (12-152): 1.24e-35: 133: 24.66
+	Mm
		952749 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		CBX5_MOUSE (12-152): 3.66e-35: 132: 25.34
+	Hs
		203659 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV91_HUMAN (12-108): 1.6e-29: 122: 25.00
+	Hs
		935237 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SUV92_HUMAN (10-109): 3.45e-28: 118: 22.43
+	Mm
		952761 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		CBX7_MOUSE (3-117): 1.22e-29: 115: 42.24