HitPredict

Interactor 1: FBLN4 (O95967)
EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)
Gene: EFEMP2

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 1731
+	Hs
		804330 NOTC1_HUMAN (5-404): 6.78e-21: 98: 15.39		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1231801 LTBP4_HUMAN (35-279): 2.15e-15: 80.9: 24.54		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316288 LTBP3_HUMAN (193-369): 4.23e-14: 76.7: 21.58		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1016988 FBLN3_HUMAN (6-244): 1.09e-11: 68.7: 22.01		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316311 NOTC3_HUMAN (7-336): 2.78e-11: 67.9: 15.25		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1167035 FAT4_HUMAN (123-222): 2.6e-10: 64.9: 20.00		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Dm
		246781 TENM_DROME (242-419): 1.24e-18: 91: 8.99		Q0KIE7_DROME (30-505): 2.28e-87: 318: 16.35
+	Hs
		167042 NOTC3_HUMAN (7-336): 2.78e-11: 67.9: 15.25		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		957287 FBLN2_HUMAN (45-399): 9.48e-20: 94.5: 24.68		TNKS2_HUMAN (220-558): 1.49e-36: 153: 12.29
+	Hs
		1167037 FAT4_HUMAN (123-222): 2.6e-10: 64.9: 20.00		TNKS2_HUMAN (220-558): 1.49e-36: 153: 12.29
+	Hs
		804293 NOTC1_HUMAN (5-404): 6.78e-21: 98: 15.39		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Dm
		65546 NOTCH_DROME (5-344): 2.32e-13: 74.8: 14.46		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Dm
		114000 CUBN_DROME (4-245): 4.55e-28: 119: 17.35		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73
+	Hs
		1237561 NOTC3_HUMAN (7-336): 2.78e-11: 67.9: 15.25		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Dm
		422915 NOTCH_DROME (5-344): 2.32e-13: 74.8: 14.46		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31