HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RS27A (P62979)
Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
Gene: RPS27A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34349018, 38334954
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 156
+	Hs
		982162 UB2D2_HUMAN (4-154): 3.47e-75: 224: 41.06		RS27A_HUMAN (1-156): 3.57e-76: 225: 100.00
+	Hs
		957057 UB2D3_HUMAN (4-154): 5.66e-74: 221: 39.74		RS27A_HUMAN (1-156): 3.57e-76: 225: 100.00
+	Hs
		957589 UBE2K_HUMAN (1-200): 9.79e-83: 245: 100.00		RL40_HUMAN (1-125): 5.35e-44: 142: 64.80
+	Mm
		509007 UBE2K_MOUSE (1-200): 9.79e-83: 245: 100.00		UBC_MOUSE (1-119): 1.08e-36: 135: 67.48
+	Ce
		885152 Q9TZ69_CAEEL (1-199): 8.92e-82: 243: 52.26		RL40_CAEEL (1-125): 7.95e-42: 137: 64.00
+	Hs
		507137 UBE2K_HUMAN (1-200): 9.79e-83: 245: 100.00		UBB_HUMAN (1-76): 6.68e-36: 125: 100.00
+	Hs
		982163 UB2D2_HUMAN (4-154): 3.47e-75: 224: 41.06		RL40_HUMAN (1-125): 5.35e-44: 142: 64.80
+	Hs
		957058 UB2D3_HUMAN (4-154): 5.66e-74: 221: 39.74		RL40_HUMAN (1-125): 5.35e-44: 142: 64.80
+	Rn
		92896 UB2D1_RAT (4-154): 7.02e-76: 226: 39.74		UBC_RAT (1-119): 1.58e-36: 134: 68.29
+	Mm
		509006 UB2D3_MOUSE (4-154): 5.66e-74: 221: 39.74		UBC_MOUSE (1-119): 1.08e-36: 135: 67.48
+	At
		1167967 UBC27_ARATH (7-199): 5e-75: 225: 48.19		UBQ3_ARATH (1-77): 2.2e-35: 126: 94.81
+	Hs
		507431 UB2D4_HUMAN (4-154): 5.52e-76: 226: 41.72		UBB_HUMAN (1-76): 6.68e-36: 125: 100.00
+	At
		1167874 UBC28_ARATH (4-155): 2.98e-75: 224: 41.45		UBQ3_ARATH (1-77): 2.2e-35: 126: 94.81
+	Dm
		683066 UBCD1_DROME (4-154): 8.07e-75: 223: 41.72		Q9W418_DROME (1-77): 1.7e-34: 127: 100.00
+	Hs
		507147 UB2D2_HUMAN (4-154): 3.47e-75: 224: 41.06		UBB_HUMAN (1-76): 6.68e-36: 125: 100.00
+	At
		762746 UBC8_ARATH (4-155): 7.39e-75: 223: 41.45		UBQ3_ARATH (1-77): 2.2e-35: 126: 94.81
+	At
		762762 UBC9_ARATH (4-155): 2e-74: 222: 42.11		UBQ3_ARATH (1-77): 2.2e-35: 126: 94.81
+	At
		762777 UBC10_ARATH (4-155): 2.75e-74: 222: 41.45		UBQ3_ARATH (1-77): 2.2e-35: 126: 94.81
+	At
		762787 UBC11_ARATH (4-155): 1.68e-74: 222: 42.11		UBQ3_ARATH (1-77): 2.2e-35: 126: 94.81
+	Hs
		507136 UB2D3_HUMAN (4-154): 5.66e-74: 221: 39.74		UBB_HUMAN (1-76): 6.68e-36: 125: 100.00