Protein: UBE2K
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)

Gene: UBE2K
Organism: Homo sapiens
Interactions: 153
UniProt ID: P61086

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507756

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

22

20

Small-scale

0.990

High

957637

RN138
E3 ubiquitin-protein ligase RNF138

10

20

Small-scale

0.980

High

647523

UBA1
Ubiquitin-like modifier-activating enzyme 1

10

20

Small-scale

0.977

High

957657

RNF5
E3 ubiquitin-protein ligase RNF5

5

20

High-throughput

0.931

High

957590

UBC9
SUMO-conjugating enzyme UBC9

5

16

Small-scale

0.919

High

957629

DTX3
Probable E3 ubiquitin-protein ligase DTX3

4

20

High-throughput

0.904

High

798918

BRCA1
Breast cancer type 1 susceptibility protein

4

20

Small-scale

0.901

High

957595

RING1
E3 ubiquitin-protein ligase RING1

4

20

High-throughput

0.892

High

957664

TRIM5
Tripartite motif-containing protein 5

4

20

High-throughput

0.892

High

957692

TRI35
E3 ubiquitin-protein ligase TRIM35

4

20

High-throughput

0.892

High

957589

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

4

20

High-throughput

0.886

High

957593

MDM2
E3 ubiquitin-protein ligase Mdm2

4

14

Small-scale

0.885

High

957646

RN185
E3 ubiquitin-protein ligase RNF185

4

20

Small-scale

0.885

High

957653

RING2
E3 ubiquitin-protein ligase RING2

3

20

Small-scale

0.872

High

957618

RN111
E3 ubiquitin-protein ligase Arkadia

3

20

High-throughput

0.849

High

957671

RN167
E3 ubiquitin-protein ligase RNF167

3

20

Small-scale

0.849

High

957682

APC11
Anaphase-promoting complex subunit 11

3

20

Small-scale

0.845

High

186525

TRI18
E3 ubiquitin-protein ligase Midline-1

3

20

High-throughput

0.845

High

507137

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

20

Small-scale

0.834

High

957597

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

18

High-throughput

0.783

High

957623

TRI50
E3 ubiquitin-protein ligase TRIM50

2

20

High-throughput

0.783

High

957632

DTX3L
E3 ubiquitin-protein ligase DTX3L

2

20

High-throughput

0.783

High

957639

RN166
E3 ubiquitin-protein ligase RNF166

2

20

High-throughput

0.783

High

957642

BIRC7
Baculoviral IAP repeat-containing protein 7

2

20

High-throughput

0.783

High

957658

TRAIP
E3 ubiquitin-protein ligase TRAIP

2

9

High-throughput

0.783

High

957660

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

20

High-throughput

0.783

High

957665

TRIM2
Tripartite motif-containing protein 2

2

20

High-throughput

0.783

High

957668

RNF32
RING finger protein 32

2

1

High-throughput

0.783

High

957670

RNF41
E3 ubiquitin-protein ligase NRDP1

2

20

High-throughput

0.783

High

957688

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.783

High

957690

CBLC
E3 ubiquitin-protein ligase CBL-C

2

20

High-throughput

0.783

High

957696

RN114
E3 ubiquitin-protein ligase RNF114

2

20

High-throughput

0.783

High

957648

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.778

High

957652

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

20

Small-scale

0.778

High

957679

RNF12
E3 ubiquitin-protein ligase RLIM

2

20

Small-scale

0.778

High

957645

RN125
E3 ubiquitin-protein ligase RNF125

2

20

High-throughput

0.768

High

957588

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

20

High-throughput

0.754

High

843442

HD
Huntingtin

6

2

Small-scale

0.732

High

957672

MARH7
E3 ubiquitin-protein ligase MARCHF7

6

19

Small-scale

0.728

High

957675

TRI39
E3 ubiquitin-protein ligase TRIM39

5

20

High-throughput

0.721

High

571916

TRI27
Zinc finger protein RFP

5

20

High-throughput

0.720

High

957662

TRI31
E3 ubiquitin-protein ligase TRIM31

4

20

High-throughput

0.691

High

957683

BFAR
Bifunctional apoptosis regulator

4

20

High-throughput

0.691

High

957626

SIAH1
E3 ubiquitin-protein ligase SIAH1

3

20

High-throughput

0.680

High

957617

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

3

High-throughput

0.665

High

957605

NEDD8
Ubiquitin-like protein NEDD8

1

19

High-throughput

0.665

High

957612

Q6PIA0
Baculoviral IAP repeat-containing 8

1

20

High-throughput

0.665

High

957634

DDI1
Protein DDI1 homolog 1

1

7

High-throughput

0.662

High

957594

REL
Proto-oncogene c-Rel

2

8

High-throughput

0.651

High

131879

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.647

High

241260

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

258264

TRI13
E3 ubiquitin-protein ligase TRIM13

1

20

Small-scale

0.647

High

957598

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

13

Small-scale

0.647

High

957608

RN213
E3 ubiquitin-protein ligase RNF213

1

3

Small-scale

0.647

High

957630

PJA1
E3 ubiquitin-protein ligase Praja-1

1

20

Small-scale

0.647

High

957638

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

Small-scale

0.647

High

957644

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

957663

TRIM6
Tripartite motif-containing protein 6

1

20

Small-scale

0.647

High

957666

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

19

Small-scale

0.647

High

957674

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

20

Small-scale

0.647

High

957689

AMFR
E3 ubiquitin-protein ligase AMFR

1

20

Small-scale

0.647

High

957631

MIPO1
Mirror-image polydactyly gene 1 protein

3

0

High-throughput

0.646

High

957694

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.630

High

957676

DBLOH
Diablo IAP-binding mitochondrial protein

2

1

Small-scale

0.629

High

957627

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.622

High

322552

RNF37
RING finger protein 37

1

7

High-throughput

0.621

High

898212

R144A
E3 ubiquitin-protein ligase RNF144A

1

20

High-throughput

0.621

High

957592

RNF4
E3 ubiquitin-protein ligase RNF4

1

20

High-throughput

0.621

High

957613

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

12

High-throughput

0.621

High

957614

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

8

High-throughput

0.621

High

957621

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

9

High-throughput

0.621

High

957624

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.621

High

957650

BIRC8
Baculoviral IAP repeat-containing protein 8

1

20

High-throughput

0.621

High

957651

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

10

High-throughput

0.621

High

957591

H31
Histone H3.1

1

4

Small-scale

0.618

High

957599

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

8

High-throughput

0.618

High

957687

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

139120

KRIT1
Krev interaction trapped protein 1

2

4

High-throughput

0.606

High

140208

SDCB1
Syntenin-1

2

3

High-throughput

0.606

High

666819

CCNC
Cyclin-C

2

4

High-throughput

0.606

High

957622

MARH3
E3 ubiquitin-protein ligase MARCHF3

2

20

High-throughput

0.606

High

957628

RN182
E3 ubiquitin-protein ligase RNF182

2

20

High-throughput

0.606

High

957641

TRI43
Tripartite motif-containing protein 43

2

20

High-throughput

0.606

High

957677

PICK1
PRKCA-binding protein

2

2

High-throughput

0.606

High

822562

VHL
von Hippel-Lindau disease tumor suppressor

2

4

High-throughput

0.601

High

957669

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

4

High-throughput

0.594

High

957697

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.589

High

517286

ZTRF1
Zinc finger TRAF-type-containing protein 1

2

20

High-throughput

0.584

High

685148

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

957600

EXOS7
Exosome complex component RRP42

2

0

High-throughput

0.580

High

957603

TSN
Translin

2

0

High-throughput

0.580

High

957643

RN183
E3 ubiquitin-protein ligase RNF183

2

0

High-throughput

0.580

High

957607

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.575

High

957681

ARL15
ADP-ribosylation factor-like protein 15

2

1

High-throughput

0.574

High

413512

P53
Cellular tumor antigen p53

1

6

Small-scale

0.552

High

484465

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

957656

CDC6
Cell division control protein 6 homolog

1

0

High-throughput

0.518

High

573786

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.515

High

775639

DEK
Protein DEK

1

1

High-throughput

0.515

High

250529

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.515

High

301386

WFS1
Wolframin

1

1

High-throughput

0.515

High

957587

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.515

High

957596

TP53B
TP53-binding protein 1

1

3

High-throughput

0.515

High

957609

ADAL
N6-Methyl-AMP deaminase

1

1

High-throughput

0.515

High

957610

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

957640

SPSB1
SPRY domain-containing SOCS box protein 1

1

13

High-throughput

0.515

High

957654

SPSB2
SPRY domain-containing SOCS box protein 2

1

9

High-throughput

0.515

High

957695

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

High-throughput

0.515

High

957602

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

957604

ITSN1
Intersectin-1

1

4

High-throughput

0.508

High

317154

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.501

High

345053

RIGI
Antiviral innate immune response receptor RIG-I

1

4

Small-scale

0.501

High

957616

CASPC
Inactive caspase-12

1

1

Small-scale

0.501

High

957655

BARD1
BRCA1-associated RING domain protein 1

1

11

Small-scale

0.501

High

957673

RC3H2
Roquin-2

1

8

Small-scale

0.501

High

957691

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.501

High

957625

ZDH17
Palmitoyltransferase ZDHHC17

1

8

High-throughput

0.494

High

185085

TELT
Telethonin

1

0

High-throughput

0.493

High

305835

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.493

High

488438

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

High-throughput

0.493

High

957635

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

957636

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.493

High

957649

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.493

High

957680

DDIT4
DNA damage-inducible transcript 4 protein

1

0

High-throughput

0.493

High

893794

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

957659

TRI34
E3 ubiquitin-protein ligase TRIM34

1

20

High-throughput

0.481

High

957667

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

18

High-throughput

0.481

High

957684

SENP1
Sentrin-specific protease 1

1

0

Small-scale

0.480

High

259708

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

347614

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

529477

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.479

High

536871

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

567333

TCTP
Translationally-controlled tumor protein

1

5

High-throughput

0.479

High

648123

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.479

High

695090

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

830456

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

957601

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

Small-scale

0.479

High

957619

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

957678

HELLS
Lymphoid-specific helicase

1

2

Small-scale

0.479

High

957686

ZRAN1
Ubiquitin thioesterase ZRANB1

1

17

High-throughput

0.479

High

280565

PR40A
Pre-mRNA-processing factor 40 homolog A

1

20

High-throughput

0.464

High

957633

ZN384
Zinc finger protein 384

1

0

High-throughput

0.460

High

957685

NXF1
Nuclear RNA export factor 1

1

0

Small-scale

0.458

High

105678

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

379978

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

957693

XCT
Cystine/glutamate transporter

1

1

Small-scale

0.437

High

886698

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

957661

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

0

High-throughput

0.282

High

957615

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

957606

GRPL2
GLIPR1-like protein 2

1

0

High-throughput

0.268

Low

957611

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.268

Low

957620

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

0

High-throughput

0.268

Low

957647

F163A
Protein FAM163A

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025