HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0006974 - DNA damage response
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 538
+	Hs
		508856 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		LIS1_HUMAN (104-423): 9.57e-53: 186: 9.65
+	Hs
		509143 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38
+	Hs
		509088 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		509081 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		973406 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38
+	Hs
		973382 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		973378 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56