HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	35235311, 26592444, 38334954
Identification Methods	cross-linking study, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UBA~ubiquitin, UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 200
+	Hs
		507756 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBE2K_HUMAN (1-200): 9.79e-83: 245: 100.00
+	Hs
		507431 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UB2D4_HUMAN (4-154): 5.52e-76: 226: 41.72
+	Hs
		507147 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UB2D2_HUMAN (4-154): 3.47e-75: 224: 41.06
+	Hs
		507701 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UB2D1_HUMAN (4-154): 7.02e-76: 226: 39.74
+	Hs
		508868 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UB2D4_HUMAN (4-154): 5.52e-76: 226: 41.72
+	Hs
		507136 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UB2D3_HUMAN (4-154): 5.66e-74: 221: 39.74
+	Hs
		507793 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UB2D2_HUMAN (4-154): 3.47e-75: 224: 41.06
+	Xl
		982387 Q7SY79_XENLA (1-228): 1.28e-92: 285: 100.00		UB2D2_XENLA (4-154): 3.47e-75: 224: 41.06
+	Dm
		683066 Q9W418_DROME (1-228): 1.41e-93: 285: 100.00		UBCD1_DROME (4-154): 8.07e-75: 223: 41.72
+	Hs
		507755 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UB2D3_HUMAN (4-154): 5.66e-74: 221: 39.74
+	Hs
		1217033 Q5U5U6_HUMAN (1-229): 2.65e-99: 289: 100.00		UB2E3_HUMAN (3-153): 4.5e-68: 208: 40.40
+	Hs
		507301 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UB2E3_HUMAN (3-153): 4.5e-68: 208: 40.40
+	Hs
		508456 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UB2E2_HUMAN (3-153): 2.06e-68: 209: 40.40
+	Hs
		507116 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UBE2A_HUMAN (1-151): 3.89e-67: 204: 30.46
+	Hs
		508388 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UB2E3_HUMAN (3-153): 4.5e-68: 208: 40.40
+	Hs
		507680 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBE2A_HUMAN (1-151): 3.89e-67: 204: 30.46
+	Hs
		507705 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UB2E1_HUMAN (3-153): 1.14e-66: 204: 39.74
+	Hs
		507138 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		UBE2N_HUMAN (27-153): 1.06e-37: 129: 51.97
+	Dr
		99090 F1QHN6_DANRE (1-228): 2.15e-93: 284: 100.00		Q7T3F3_DANRE (43-154): 5.69e-39: 132: 57.14
+	Hs
		507757 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBE2N_HUMAN (27-153): 1.06e-37: 129: 51.97