HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: UB2V1 (Q13404)
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)
Gene: UBE2V1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 18029035, 18082144, 27173435, 32659264, 11057907, 20613989, 16215985, 18678647, 17709375, 25548215, 29069608, 29662619, 29537486, 33961781, 16307917, 16129784, 15147900, 22367539, 26101372, 21460221 and 1 others

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Identification Methods pull down, affinity chromatography technology, biochemical, two hybrid, molecular sieving, ubiquitinase assay, enzymatic study, anti tag coimmunoprecipitation, mass spectrometry studies of complexes
Interaction Type direct interaction, physical association, association, ubiquitination reaction, deubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~UQ_con
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 12 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 152
Hs

1 147
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Service provided by Combinatics, Japan

Last updated: 11Aug2025