HitPredict

Interactor 1: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	26638075, 28514442, 33961781, 27173435, 34079125, unassigned3799
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005875 - microtubule associated complex GO:0005938 - cell cortex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 1278
+	Hs
		837224 ACTY_HUMAN (1-376): 0: 728: 90.43		DCTN1_HUMAN (1-1278): 7.7e-92: 325: 100.00
+	Hs
		952814 ACTB_HUMAN (7-376): 0: 581: 52.41		DCTN1_HUMAN (1-1278): 7.7e-92: 325: 100.00
+	Hs
		993175 ACTG_HUMAN (7-376): 0: 581: 52.67		DCTN1_HUMAN (1-1278): 7.7e-92: 325: 100.00
+	Hs
		977697 ACTA_HUMAN (5-376): 0: 576: 52.66		DCTN1_HUMAN (1-1278): 7.7e-92: 325: 100.00
+	Hs
		995587 ACTC_HUMAN (5-376): 0: 576: 52.93		DCTN1_HUMAN (1-1278): 7.7e-92: 325: 100.00
+	Hs
		720978 ACTZ_HUMAN (1-376): 0: 771: 100.00		CLIP1_HUMAN (111-828): 1.38e-21: 104: 11.32
+	Dm
		562666 ACTZ_DROME (1-376): 0: 649: 79.26		DCTN1_DROME (23-1236): 1.44e-56: 217: 31.58
+	Hs
		720960 ACTY_HUMAN (1-376): 0: 728: 90.43		CLIP1_HUMAN (111-828): 1.38e-21: 104: 11.32
+	Rn
		953311 ACTB_RAT (7-376): 0: 581: 52.41		MYH10_RAT (66-1056): 2.59e-42: 172: 12.23
+	Mm
		977876 ACTA_MOUSE (5-376): 0: 576: 52.66		MYH6_MOUSE (47-740): 5.08e-26: 119: 10.09
+	Hs
		773154 ACTC_HUMAN (5-376): 0: 576: 52.93		MYH10_HUMAN (728-1267): 1.06e-20: 101: 9.02
+	Hs
		773153 ACTH_HUMAN (7-376): 0: 573: 52.94		MYH10_HUMAN (728-1267): 1.06e-20: 101: 9.02
+	Hs
		772705 ACTB_HUMAN (7-376): 0: 581: 52.41		MYH9_HUMAN (814-1277): 9.23e-16: 85.2: 11.35
+	Hs
		772729 ACTG_HUMAN (7-376): 0: 581: 52.67		MYH9_HUMAN (814-1277): 9.23e-16: 85.2: 11.35
+	Hs
		772733 ACTC_HUMAN (5-376): 0: 576: 52.93		MYH9_HUMAN (814-1277): 9.23e-16: 85.2: 11.35
+	Hs
		772734 ACTS_HUMAN (5-376): 0: 576: 52.39		MYH9_HUMAN (814-1277): 9.23e-16: 85.2: 11.35
+	Mm
		953280 ACTB_MOUSE (7-376): 0: 581: 52.41		MYH9_MOUSE (827-1270): 2.19e-13: 77.5: 12.67
+	Rn
		953303 ACTB_RAT (7-376): 0: 581: 52.41		MYH9_RAT (829-1270): 2.73e-13: 77.2: 13.27
+	Ce
		95483 Q9NA98_CAEEL (4-376): 0: 555: 70.24		E2JKZ0_CAEEL (42-637): 2.28e-12: 73.9: 15.31