HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: HOOK1 (Q9UJC3)
Protein Hook homolog 1 (h-hook1) (hHK1)
Gene: HOOK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 728
+	Hs
		528401 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		MYH8_HUMAN (1-662): 3.96e-29: 127: 10.88
+	Hs
		625177 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		MYH10_HUMAN (1-650): 2.97e-29: 127: 11.47
+	Hs
		528405 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH8_HUMAN (1-662): 3.96e-29: 127: 10.88
+	Hs
		528368 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH6_HUMAN (1-726): 2.55e-28: 124: 9.85
+	Hs
		522542 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH1_HUMAN (19-691): 4.65e-28: 123: 11.55
+	Hs
		960128 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH2_HUMAN (1-691): 1.05e-27: 122: 10.86
+	Hs
		960129 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH13_HUMAN (12-662): 6.28e-27: 120: 10.88
+	Hs
		625176 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		MYH9_HUMAN (1-550): 5.58e-23: 107: 13.78
+	Hs
		725114 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		MYH10_HUMAN (1-650): 2.97e-29: 127: 11.47
+	Hs
		522604 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH7_HUMAN (1-437): 2.81e-15: 82.4: 11.21
+	Hs
		502908 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH3_HUMAN (44-522): 9.95e-14: 77.4: 11.78
+	Hs
		724717 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		MYH9_HUMAN (1-550): 5.58e-23: 107: 13.78
+	Hs
		625530 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		MY18A_HUMAN (247-697): 1.83e-10: 66.9: 17.26
+	Hs
		61854 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		CC88B_HUMAN (157-597): 2.1e-10: 66.5: 20.61
+	Hs
		989706 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		HOOK2_HUMAN (306-714): 5.05e-09: 61.7: 13.01