HitPredict

Interactor 1: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Interactor 2: SSBP4 (Q9BWG4)
Single-stranded DNA-binding protein 4
Gene: SSBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	26186194, 28514442, 33961781, 24981860, 20211142
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 349 Hs			1 385
+	Hs
		1382429 ISL2_HUMAN (1-349): 4.2e-81: 252: 73.35		SSBP4_HUMAN (1-385): 6.03e-71: 228: 100.00
+	Hs
		961491 ISL1_HUMAN (1-349): 5.39e-91: 278: 100.00		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Mm
		961502 ISL1_MOUSE (1-349): 5.39e-91: 278: 100.00		SSBP3_MOUSE (6-385): 7.35e-54: 184: 70.03
+	Mm
		1189923 ISL2_MOUSE (1-349): 4.15e-81: 252: 72.21		Q3U4B1_MOUSE (1-385): 1.9e-54: 185: 83.68
+	Hs
		1382430 ISL2_HUMAN (1-349): 4.2e-81: 252: 73.35		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Mm
		1423865 ISL2_MOUSE (1-349): 4.15e-81: 252: 72.21		SSBP3_MOUSE (6-385): 7.35e-54: 184: 70.03
+	Mm
		961501 ISL1_MOUSE (1-349): 5.39e-91: 278: 100.00		SSBP2_MOUSE (1-385): 5.08e-44: 157: 69.77
+	Hs
		961475 ISL1_HUMAN (1-349): 5.39e-91: 278: 100.00		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Hs
		1416155 LHX9_HUMAN (3-307): 6.31e-61: 202: 26.33		SSBP4_HUMAN (1-385): 6.03e-71: 228: 100.00
+	Hs
		895791 LHX2_HUMAN (3-316): 2e-59: 198: 26.10		SSBP4_HUMAN (1-385): 6.03e-71: 228: 100.00
+	Mm
		1423864 ISL2_MOUSE (1-349): 4.15e-81: 252: 72.21		SSBP2_MOUSE (1-385): 5.08e-44: 157: 69.77
+	Hs
		1010768 ISL2_HUMAN (1-349): 4.2e-81: 252: 73.35		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Hs
		1416425 LHX9_HUMAN (3-307): 6.31e-61: 202: 26.33		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Mm
		1423948 LHX2_MOUSE (3-316): 1.98e-60: 200: 26.37		SSBP3_MOUSE (6-385): 7.35e-54: 184: 70.03
+	Mm
		1189925 LHX9_MOUSE (3-307): 2.58e-59: 197: 26.33		Q3U4B1_MOUSE (1-385): 1.9e-54: 185: 83.68
+	Hs
		895792 LHX2_HUMAN (3-316): 2e-59: 198: 26.10		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Mm
		1423945 LHX9_MOUSE (3-307): 2.58e-59: 197: 26.33		SSBP3_MOUSE (6-385): 7.35e-54: 184: 70.03
+	Mm
		1423892 LHX2_MOUSE (3-316): 1.98e-60: 200: 26.37		SSBP2_MOUSE (1-385): 5.08e-44: 157: 69.77
+	Mm
		1423891 LHX9_MOUSE (3-307): 2.58e-59: 197: 26.33		SSBP2_MOUSE (1-385): 5.08e-44: 157: 69.77
+	Hs
		895698 LHX2_HUMAN (3-316): 2e-59: 198: 26.10		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51