Protein: ISL1
Insulin gene enhancer protein ISL-1 (Islet-1)

Gene: ISL1
Organism: Homo sapiens
Interactions: 39
UniProt ID: P61371

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

961487

LHX4
LIM/homeobox protein Lhx4

5

19

High-throughput

0.928

High

961481

LDB1
LIM domain-binding protein 1

5

20

Small-scale

0.911

High

961490

SSBP4
Single-stranded DNA-binding protein 4

5

20

High-throughput

0.720

High

223927

LDB2
LIM domain-binding protein 2

1

20

High-throughput

0.698

High

842906

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

3

High-throughput

0.698

High

961483

ZN511
Zinc finger protein 511

4

1

High-throughput

0.698

High

961475

SSBP2
Single-stranded DNA-binding protein 2

4

20

High-throughput

0.694

High

961491

SSBP3
Single-stranded DNA-binding protein 3

4

20

High-throughput

0.694

High

681778

RBTN2
Rhombotin-2

1

19

Small-scale

0.647

High

961474

ISL1
Insulin gene enhancer protein ISL-1

1

18

Small-scale

0.647

High

961485

LMX1A
LIM homeobox transcription factor 1-alpha

1

18

Small-scale

0.647

High

961488

ISL2
Insulin gene enhancer protein ISL-2

1

20

Small-scale

0.647

High

961493

LHX3
LIM/homeobox protein Lhx3

1

19

Small-scale

0.647

High

961495

ARI1
E3 ubiquitin-protein ligase ARIH1

2

3

High-throughput

0.628

High

961489

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

6

High-throughput

0.618

High

405970

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.618

High

599279

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

1

High-throughput

0.576

High

855570

CRK
Adapter molecule crk

2

10

High-throughput

0.576

High

395803

ESR1
Estrogen receptor

1

7

Small-scale

0.561

High

833908

HNF4A
Hepatocyte nuclear factor 4-alpha

1

7

Small-scale

0.561

High

961477

CDK6
Cyclin-dependent kinase 6

1

4

Small-scale

0.550

High

961476

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.541

High

961478

TF65
Transcription factor p65

1

7

High-throughput

0.541

High

340862

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

11

High-throughput

0.536

High

961479

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

961486

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

961494

PYGO1
Pygopus homolog 1

1

20

High-throughput

0.536

High

246512

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.508

High

421844

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

522813

COT1
COUP transcription factor 1

1

8

Small-scale

0.501

High

284300

GEMI
Geminin

1

0

Small-scale

0.480

High

138988

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

272636

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

5

Small-scale

0.479

High

961480

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

6

Small-scale

0.479

High

961482

BCL9L
B-cell CLL/lymphoma 9-like protein

1

20

High-throughput

0.479

High

961484

MAFA
Transcription factor MafA

1

1

Small-scale

0.479

High

961496

MAFB
Transcription factor MafB

1

1

Small-scale

0.479

High

961492

PECR
Peroxisomal trans-2-enoyl-CoA reductase

1

0

Small-scale

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025