HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1190
+	Hs
		466510 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		961986 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ZO1_HUMAN (25-1176): 1.61e-132: 446: 36.74
+	Hs
		962140 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MPP7_HUMAN (434-892): 2.49e-93: 313: 16.00
+	Hs
		988429 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		MPP7_HUMAN (434-892): 2.49e-93: 313: 16.00
+	Hs
		168669 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		CSKP_HUMAN (229-890): 7.83e-90: 312: 14.96
+	Hs
		466300 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		MPP7_HUMAN (434-892): 2.49e-93: 313: 16.00
+	Hs
		1015503 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		MPP7_HUMAN (434-892): 2.49e-93: 313: 16.00
+	Hs
		168672 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		CSKP_HUMAN (229-890): 7.83e-90: 312: 14.96
+	Mm
		988891 RAC1_MOUSE (1-193): 7e-79: 235: 57.22		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Hs
		961999 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		DLG1_HUMAN (1-423): 1.41e-47: 186: 18.25
+	Hs
		988325 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		DLG1_HUMAN (1-423): 1.41e-47: 186: 18.25
+	Hs
		466228 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		DLG1_HUMAN (1-423): 1.41e-47: 186: 18.25
+	Hs
		1015397 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		DLG1_HUMAN (1-423): 1.41e-47: 186: 18.25
+	Hs
		962263 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		PALS1_HUMAN (455-886): 1.78e-39: 159: 19.67
+	Hs
		962343 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		DLG3_HUMAN (2-123): 6.12e-23: 107: 27.42
+	Hs
		1015652 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		DLG3_HUMAN (2-123): 6.12e-23: 107: 27.42
+	Hs
		962303 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77
+	Hs
		988547 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77
+	Hs
		466375 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77
+	Hs
		1015625 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77