HitPredict

Interactor 1: UCHL1 (Q00981)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22871113
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Peptidase_C12~ubiquitin
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 223 Rn			1 810
+	Hs
		456475 UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		476639 UCHL5_HUMAN (2-220): 1.14e-100: 296: 22.12		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		475307 UCHL3_HUMAN (2-222): 1.19e-100: 293: 53.10		UBC_HUMAN (1-533): 0: 662: 99.81
+	Hs
		476130 BAP1_HUMAN (3-220): 4.12e-78: 250: 22.69		UBC_HUMAN (1-533): 0: 662: 99.81
+	Sc
		477215 UBL1_YEAST (5-219): 2.06e-55: 178: 27.16		UBI4P_YEAST (457-801): 3.68e-132: 400: 90.73
+	Hs
		456536 UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00
+	Mm
		477056 UCHL5_MOUSE (2-220): 4.41e-101: 297: 22.12		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74
+	Mm
		477047 UCHL1_MOUSE (1-223): 1.11e-101: 295: 100.00		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74
+	Mm
		477030 UCHL3_MOUSE (2-222): 3.64e-100: 291: 53.98		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74
+	Mm
		476730 UCHL4_MOUSE (2-222): 1.15e-96: 283: 52.40		UBC_MOUSE (1-108): 6.19e-31: 132: 90.74
+	Hs
		398154 UCHL5_HUMAN (2-220): 1.14e-100: 296: 22.12		ISG15_HUMAN (228-380): 7.21e-29: 115: 32.69
+	Hs
		456474 UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70
+	Hs
		474910 UCHL3_HUMAN (2-222): 1.19e-100: 293: 53.10		UBB_HUMAN (1-77): 1.17e-26: 110: 98.70
+	Hs
		548107 UCHL3_HUMAN (2-222): 1.19e-100: 293: 53.10		Q5U5U6_HUMAN (1-77): 1.17e-26: 110: 98.70
+	Hs
		924096 BAP1_HUMAN (3-220): 4.12e-78: 250: 22.69		RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00