Protein: S39A6
Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)

Gene: S39A6, SLC39A6
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q13433

Gene Ontology (top 5):
GO:0001837 - epithelial to mesenchymal transition
GO:0005385 - zinc ion transmembrane transporter activity
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane
GO:0006882 - intracellular zinc ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1105207

S39A5
Zinc transporter ZIP5

3

8

High-throughput

0.855

High

212396

SPIT2
Kunitz-type protease inhibitor 2

3

9

High-throughput

0.667

High

1105203

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.606

High

702770

5HT2C
5-hydroxytryptamine receptor 2C

2

9

High-throughput

0.601

High

375485

RASK
GTPase KRas

2

20

High-throughput

0.584

High

977981

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

1105260

S39AA
Zinc transporter ZIP10

1

8

High-throughput

0.575

High

1105211

RETR3
Reticulophagy regulator 3

2

3

High-throughput

0.553

High

1105229

B2CL2
Bcl-2-like protein 2

2

1

High-throughput

0.553

High

133246

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.536

High

182524

GP182
G-protein coupled receptor 182

1

15

High-throughput

0.536

High

221452

OX2R
Orexin receptor type 2

1

6

High-throughput

0.536

High

275810

CAD16
Cadherin-16

1

10

High-throughput

0.536

High

351893

S1PR4
Sphingosine 1-phosphate receptor 4

1

20

High-throughput

0.536

High

380284

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

15

High-throughput

0.536

High

520831

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

13

High-throughput

0.536

High

607368

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

13

High-throughput

0.536

High

689823

CD27
CD27 antigen

1

10

High-throughput

0.536

High

698631

CALX
Calnexin

1

6

High-throughput

0.536

High

833817

P2RY2
P2Y purinoceptor 2

1

20

High-throughput

0.536

High

936041

PAR2
Proteinase-activated receptor 2

1

20

High-throughput

0.536

High

1105209

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

12

High-throughput

0.536

High

1105213

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

20

High-throughput

0.536

High

1105226

CLC2B
C-type lectin domain family 2 member B

1

6

High-throughput

0.536

High

1105232

T106A
Transmembrane protein 106A

1

7

High-throughput

0.536

High

1105238

CNTP3
Contactin-associated protein-like 3

1

7

High-throughput

0.536

High

1105245

LPAR2
Lysophosphatidic acid receptor 2

1

20

High-throughput

0.536

High

1105246

GPR35
G-protein coupled receptor 35

1

18

High-throughput

0.536

High

1105247

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.536

High

1105253

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.536

High

1105259

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

10

High-throughput

0.536

High

1105262

PCDB3
Protocadherin beta-3

1

3

High-throughput

0.536

High

1105263

PCDC2
Protocadherin alpha-C2

1

4

High-throughput

0.536

High

1105264

GPR45
Probable G-protein coupled receptor 45

1

14

High-throughput

0.536

High

341303

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.513

High

529744

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

1105256

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.513

High

880912

MTR1B
Melatonin receptor type 1B

1

6

High-throughput

0.508

High

567849

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.489

High

1022384

IDD
Integral membrane protein DGCR2/IDD

1

6

High-throughput

0.489

High

1105220

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

2

High-throughput

0.489

High

1105240

KLK15
Kallikrein-15

1

7

High-throughput

0.489

High

1105243

SPRNG
SREBP regulating gene protein

1

2

High-throughput

0.489

High

126577

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

189550

STX7
Syntaxin-7

1

10

High-throughput

0.479

High

218147

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

341045

DIRA3
GTP-binding protein Di-Ras3

1

9

High-throughput

0.479

High

363231

EGFR
Epidermal growth factor receptor

1

16

High-throughput

0.479

High

373910

RASN
GTPase NRas

1

20

High-throughput

0.479

High

374568

RASH
GTPase HRas

1

16

High-throughput

0.479

High

408852

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

410816

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

17

High-throughput

0.479

High

463503

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.479

High

466237

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

540438

LAMP1
Lysosome-associated membrane glycoprotein 1

1

9

High-throughput

0.479

High

562040

LAMP2
Lysosome-associated membrane glycoprotein 2

1

9

High-throughput

0.479

High

581024

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

582775

EZRI
Ezrin

1

4

High-throughput

0.479

High

601272

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

603965

CXA1
Gap junction alpha-1 protein

1

12

High-throughput

0.479

High

658519

GLRA2
Glycine receptor subunit alpha-2

1

1

High-throughput

0.479

High

710223

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.479

High

715570

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

774333

BASI
Basigin

1

6

High-throughput

0.479

High

799076

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

845627

MUC18
Cell surface glycoprotein MUC18

1

7

High-throughput

0.479

High

880537

LMAN1
Protein ERGIC-53

1

6

High-throughput

0.479

High

900799

RAB5C
Ras-related protein Rab-5C

1

11

High-throughput

0.479

High

901795

RAB9A
Ras-related protein Rab-9A

1

13

High-throughput

0.479

High

910036

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

953425

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955130

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962016

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962731

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975018

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

988337

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1004049

CXAR
Coxsackievirus and adenovirus receptor

1

6

High-throughput

0.479

High

1015414

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1041045

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1057682

TNR9
Tumor necrosis factor receptor superfamily member 9

1

11

High-throughput

0.479

High

1087098

STX4
Syntaxin-4

1

10

High-throughput

0.479

High

1105200

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.479

High

1105201

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1105202

OCLN
Occludin

1

3

High-throughput

0.479

High

1105205

SCAR3
Scavenger receptor class A member 3

1

1

High-throughput

0.479

High

1105206

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1105208

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1105218

CXD3
Gap junction delta-3 protein

1

12

High-throughput

0.479

High

1105223

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.479

High

1105228

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1105230

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

6

High-throughput

0.479

High

1105234

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1105236

SEC62
Translocation protein SEC62

1

4

High-throughput

0.479

High

1105241

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1105242

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1105244

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1105252

ELOV5
Very long chain fatty acid elongase 5

1

7

High-throughput

0.479

High

1105261

LAMP3
Lysosome-associated membrane glycoprotein 3

1

9

High-throughput

0.479

High

418658

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

High-throughput

0.458

High

869590

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

Small-scale

0.458

High

1105216

LYPD6
Ly6/PLAUR domain-containing protein 6

1

0

High-throughput

0.458

High

1105235

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

465510

IGF1R
Insulin-like growth factor 1 receptor

1

10

High-throughput

0.445

High

571426

GLU2B
Glucosidase 2 subunit beta

1

1

High-throughput

0.445

High

638188

S1PR1
Sphingosine 1-phosphate receptor 1

1

20

High-throughput

0.445

High

704006

5HT1E
5-hydroxytryptamine receptor 1E

1

8

High-throughput

0.445

High

907011

CCR6
C-C chemokine receptor type 6

1

8

High-throughput

0.445

High

948814

CD81
CD81 antigen

1

7

High-throughput

0.445

High

1101480

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.445

High

1105196

OS9
Protein OS-9

1

2

High-throughput

0.445

High

1105197

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

10

High-throughput

0.445

High

1105198

LRC32
Transforming growth factor beta activator LRRC32

1

2

High-throughput

0.445

High

1105199

FAT1
Protocadherin Fat 1

1

4

High-throughput

0.445

High

1105219

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.445

High

1105221

GOLM1
Golgi membrane protein 1

1

7

High-throughput

0.445

High

1105224

GP156
Probable G-protein coupled receptor 156

1

3

High-throughput

0.445

High

1105225

AGRV1
Adhesion G-protein coupled receptor V1

1

12

High-throughput

0.445

High

1105227

LPAR1
Lysophosphatidic acid receptor 1

1

20

High-throughput

0.445

High

1105237

S1PR3
Sphingosine 1-phosphate receptor 3

1

20

High-throughput

0.445

High

1105239

METL9
Protein-L-histidine N-pros-methyltransferase

1

7

High-throughput

0.445

High

181703

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.437

High

327251

ZFPL1
Zinc finger protein-like 1

1

7

High-throughput

0.437

High

630789

RAB4A
Ras-related protein Rab-4A

1

11

High-throughput

0.437

High

956277

RAB2A
Ras-related protein Rab-2A

1

11

High-throughput

0.437

High

976245

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.437

High

1004525

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

1005536

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

1

2

High-throughput

0.437

High

1105212

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

8

High-throughput

0.437

High

1105214

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1105215

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

1105231

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

1105233

WBP1
WW domain-binding protein 1

1

2

High-throughput

0.437

High

1105254

TM216
Transmembrane protein 216

1

3

High-throughput

0.437

High

1105255

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

7

High-throughput

0.437

High

1105258

KDM5B
Lysine-specific demethylase 5B

1

1

Small-scale

0.437

High

165801

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

0

High-throughput

0.426

High

1105248

SO1B3
Solute carrier organic anion transporter family member 1B3

1

0

High-throughput

0.426

High

186417

TM9S1
Transmembrane 9 superfamily member 1

1

4

High-throughput

0.407

High

906403

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.407

High

1105210

RIC3
Protein RIC-3

1

1

High-throughput

0.407

High

1105217

GLBL2
Beta-galactosidase-1-like protein 2

1

6

High-throughput

0.407

High

1105222

UXS1
UDP-glucuronic acid decarboxylase 1

1

5

High-throughput

0.407

High

1105250

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

5

High-throughput

0.407

High

1105257

FA8A1
Protein FAM8A1

1

1

High-throughput

0.407

High

522263

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

1105204

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

1105249

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.232

Low

1105251

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.232

Low

1105265

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025