HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	24457600, 20211142
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 746
+	Hs
		1080190 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080268 EYA1_HUMAN (3-277): 2.81e-39: 154: 21.07		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		726851 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		212146 HTSF1_HUMAN (310-448): 3.35e-28: 122: 20.55		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		967436 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10
+	Mm
		1142793 EWS_MOUSE (1-656): 4.67e-42: 163: 94.06		ASH1L_MOUSE (362-733): 1.26e-69: 251: 20.93
+	Hs
		203633 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Sc
		633962 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		SET2_YEAST (470-733): 1.22e-59: 216: 25.56
+	Hs
		967120 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54