Protein: HACE1
E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)

Gene: HACE1
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q8IYU2

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

988513

RAC1
Ras-related C3 botulinum toxin substrate 1

9

20

Small-scale

0.979

High

995991

UB2L3
Ubiquitin-conjugating enzyme E2 L3

8

20

Small-scale

0.968

High

1315561

HACE1
E3 ubiquitin-protein ligase HACE1

3

14

Small-scale

0.882

High

1315565

OPTN
Optineurin

1

17

Small-scale

0.784

High

630877

RAB4A
Ras-related protein Rab-4A

3

2

Small-scale

0.759

High

909087

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

62979

POTEF
POTE ankyrin domain family member F

1

7

High-throughput

0.665

High

982241

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.647

High

1096457

PAK1
Serine/threonine-protein kinase PAK 1

1

19

Small-scale

0.647

High

624092

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

20

Small-scale

0.618

High

839315

MTOR
Serine/threonine-protein kinase mTOR

1

10

Small-scale

0.618

High

976399

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.586

High

1288872

NOXA1
NADPH oxidase activator 1

1

0

Small-scale

0.586

High

1315563

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.586

High

666865

CCNC
Cyclin-C

1

5

Small-scale

0.578

High

1315568

SNTG2
Gamma-2-syntrophin

1

11

Small-scale

0.536

High

1315564

IRF7
Interferon regulatory factor 7

1

2

High-throughput

0.536

High

1315567

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

3

High-throughput

0.536

High

832609

CASR
Extracellular calcium-sensing receptor

1

1

Small-scale

0.512

High

520606

RARA
Retinoic acid receptor alpha

1

11

Small-scale

0.479

High

533228

RARB
Retinoic acid receptor beta

1

11

Small-scale

0.479

High

565529

RARG
Retinoic acid receptor gamma

1

11

Small-scale

0.479

High

994652

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.479

High

1156678

NF2L2
Nuclear factor erythroid 2-related factor 2

1

13

Small-scale

0.479

High

1315562

RPTOR
Regulatory-associated protein of mTOR

1

9

Small-scale

0.479

High

1315566

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

8

High-throughput

0.479

High

1315569

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

269686

PLXA2
Plexin-A2

1

1

Small-scale

0.457

High


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Last updated: 11Aug2025