Protein: UBE3B
Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)

Gene: UBE3B
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q7Z3V4

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005739 - mitochondrion
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0014069 - postsynaptic density
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507251

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.691

High

883272

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

Small-scale

0.647

High

957774

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1103912

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

Small-scale

0.647

High

1154272

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.647

High

1277546

UBE3B
Ubiquitin-protein ligase E3B

1

16

Small-scale

0.647

High

1010060

DLK1
Protein delta homolog 1

4

17

High-throughput

0.630

High

278520

VAMP4
Vesicle-associated membrane protein 4

1

3

High-throughput

0.536

High

867242

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

933027

SNAA
Alpha-soluble NSF attachment protein

1

1

High-throughput

0.536

High

1277550

SNAG
Gamma-soluble NSF attachment protein

1

5

High-throughput

0.536

High

372415

MYC
Myc proto-oncogene protein

1

8

Small-scale

0.528

High

1277551

EPAS1
Endothelial PAS domain-containing protein 1

1

5

Small-scale

0.528

High

1161314

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.512

High

374710

RASH
GTPase HRas

1

8

Small-scale

0.501

High

144446

SCD
Stearoyl-CoA desaturase

1

3

High-throughput

0.489

High

169113

ML12B
Myosin regulatory light chain 12B

1

11

High-throughput

0.489

High

175102

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.489

High

182628

GP182
G-protein coupled receptor 182

1

11

High-throughput

0.489

High

317192

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

4

High-throughput

0.489

High

407646

S100B
Protein S100-B

1

5

High-throughput

0.489

High

542562

TOP2A
DNA topoisomerase 2-alpha

1

5

High-throughput

0.489

High

555830

MYL4
Myosin light chain 4

1

13

High-throughput

0.489

High

634504

LMNB1
Lamin-B1

1

7

High-throughput

0.489

High

692731

CALL3
Calmodulin-like protein 3

1

12

High-throughput

0.489

High

954709

SEM1
26S proteasome complex subunit SEM1

1

2

Small-scale

0.489

High

1218326

DRC8
Dynein regulatory complex protein 8

1

13

High-throughput

0.489

High

1241459

EDC4
Enhancer of mRNA-decapping protein 4

1

5

High-throughput

0.489

High

1277553

VAMP8
Vesicle-associated membrane protein 8

1

3

High-throughput

0.489

High

1277554

ELOV1
Very long chain fatty acid elongase 1

1

1

High-throughput

0.489

High

1277556

BET1L
BET1-like protein

1

1

High-throughput

0.489

High

988481

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1277555

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.479

High

249255

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

2

High-throughput

0.470

High

617447

DNLI1
DNA ligase 1

1

1

High-throughput

0.470

High

1277548

ORAI1
Calcium release-activated calcium channel protein 1

1

1

High-throughput

0.470

High

1164444

MIC60
MICOS complex subunit MIC60

1

0

Small-scale

0.458

High

130146

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.437

High

620444

NUCL
Nucleolin

1

7

Small-scale

0.437

High

910564

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

Small-scale

0.437

High

1277547

SCD5
Stearoyl-CoA desaturase 5

1

3

High-throughput

0.437

High

1277552

MBB1A
Myb-binding protein 1A

1

2

Small-scale

0.437

High

1277559

SRRM2
Serine/arginine repetitive matrix protein 2

1

9

Small-scale

0.437

High

516352

CALM1
Calmodulin-1

1

12

High-throughput

0.407

High

516426

CALM2
Calmodulin-2

1

12

High-throughput

0.407

High

754057

CD80
T-lymphocyte activation antigen CD80

1

9

High-throughput

0.407

High

561131

GILT
Gamma-interferon-inducible lysosomal thiol reductase

3

0

High-throughput

0.347

High

1140096

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.279

Low

1198371

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

0

High-throughput

0.279

Low

1277549

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.279

Low

1277558

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.279

Low

1277557

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025