HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: CDK12 (Q9NYV4)
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)
Gene: CDK12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38113892
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 1490
+	Hs
		667644 UBE2A_HUMAN (4-150): 3.11e-64: 196: 30.46		CDK2_HUMAN (724-1026): 2.26e-140: 434: 41.12
+	Hs
		667719 UBE2H_HUMAN (1-183): 5.57e-64: 196: 100.00		CDK2_HUMAN (724-1026): 2.26e-140: 434: 41.12
+	Hs
		703527 UBE2H_HUMAN (1-183): 5.57e-64: 196: 100.00		MK01_HUMAN (713-1052): 1.98e-134: 421: 32.65
+	Hs
		443291 UBE2H_HUMAN (1-183): 5.57e-64: 196: 100.00		CDK1_HUMAN (724-1025): 1.71e-134: 418: 39.47
+	Hs
		884294 UBE2A_HUMAN (4-150): 3.11e-64: 196: 30.46		CDK9_HUMAN (724-1079): 1.52e-124: 394: 42.90
+	Hs
		897701 UBE2H_HUMAN (1-183): 5.57e-64: 196: 100.00		CDK9_HUMAN (724-1079): 1.52e-124: 394: 42.90
+	Hs
		884317 UBE2A_HUMAN (4-150): 3.11e-64: 196: 30.46		CDK5_HUMAN (724-1026): 1.17e-121: 383: 39.15
+	Hs
		970343 UBE2H_HUMAN (1-183): 5.57e-64: 196: 100.00		CDK5_HUMAN (724-1026): 1.17e-121: 383: 39.15