HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: SYDE1 (Q6ZW31)
Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)
Gene: SYDE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 735
+	Hs
		971624 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		SYDE2_HUMAN (117-703): 1.44e-93: 317: 40.66
+	Hs
		971710 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		SRGP1_HUMAN (104-732): 1.6e-93: 316: 14.01
+	Mm
		972298 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		SRGP2_MOUSE (87-734): 4.71e-87: 298: 12.74
+	Hs
		269535 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		SRGP2_HUMAN (87-734): 4.59e-86: 295: 12.74
+	Hs
		971615 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		RHG21_HUMAN (22-703): 1.72e-82: 289: 16.05
+	Mm
		972260 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		SRGP3_MOUSE (78-732): 5.5e-83: 287: 13.51
+	Hs
		74015 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		MYO9A_HUMAN (16-728): 7.86e-81: 284: 15.20
+	Hs
		539991 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		BCR_HUMAN (1-598): 4.32e-80: 280: 22.15
+	Hs
		971983 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		RGAP1_HUMAN (80-680): 7.6e-77: 261: 16.88
+	Mm
		972259 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		RHG33_MOUSE (281-633): 8.77e-72: 256: 20.22
+	Hs
		67646 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		RHG32_HUMAN (281-651): 2.5e-65: 238: 20.90
+	Hs
		971841 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		HMHA1_HUMAN (410-597): 1.76e-19: 95.9: 36.06