HitPredict

Interactor 1: HEN1 (Q02575)
Helix-loop-helix protein 1 (HEN-1) (Class A basic helix-loop-helix protein 35) (bHLHa35) (Nescient helix loop helix 1) (NSCL-1)
Gene: NHLH1

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 133 Hs			1 3969
+	Mm
		603929 TAL1_MOUSE (76-132): 6.09e-20: 84.9: 59.65		KMT2A_MOUSE (1-3969): 0: 3189: 90.32
+	Hs
		203622 TAL1_HUMAN (76-132): 3.36e-20: 85.7: 59.65		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Mm
		644484 TWST1_MOUSE (27-132): 2.2e-19: 81.5: 35.85		NSD3_MOUSE (3748-3968): 7.18e-56: 218: 25.89
+	Mm
		644495 TWST1_MOUSE (27-132): 2.2e-19: 81.5: 35.85		NSD2_MOUSE (3752-3968): 6.91e-55: 215: 27.68
+	Hs
		152628 HEN1_HUMAN (1-133): 2.02e-29: 105: 100.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47