HitPredict

Interactor 1: DYST (Q03001)
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
Gene: DST

Interactor 2: MARE1 (Q15691)
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
Gene: MAPRE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	22696216, 26186194, 26496610, 28514442, 29162697, 34079125, 33961781, 35271311, 19632184
Identification Methods	unspecified method, pull down, affinity chromatography technology, proximity labelling technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CH~CH, CH~EF-hand_7, CH~Spectrin
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0035371 - microtubule plus-end GO:0051010 - microtubule plus-end binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 7570 Hs			1 268
+	Hs
		974173 DYST_HUMAN (1-7570): 0: 2600: 100.00		MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70
+	Hs
		521551 ACTN1_HUMAN (3770-4283): 1.06e-26: 123: 10.00		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		963333 SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		1077170 MACF1_HUMAN (351-1936): 4.95e-21: 105: 11.05		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Mm
		1142238 MACF1_MOUSE (260-1747): 3.42e-16: 89.8: 9.39		MARE1_MOUSE (1-257): 1.2e-149: 420: 96.89
+	Hs
		3527 A0A0U1RQJ2_HUMAN (3002-4538): 2.19e-15: 87.1: 11.27		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		1045422 SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		1068538 PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		297830 K0754_HUMAN (1218-1826): 6.86e-10: 69: 10.48		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		551719 DESP_HUMAN (1555-1738): 2.9e-09: 67: 28.50		MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00
+	Hs
		1357665 MACF1_HUMAN (351-1936): 4.95e-21: 105: 11.05		MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70
+	Hs
		1045564 SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42		MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70
+	Dm
		54305 A1Z9J2_DROME (346-1802): 1.11e-10: 71.7: 9.03		Q9XZ57_DROME (1-265): 4e-126: 361: 52.60