Protein: LSM6
U6 snRNA-associated Sm-like protein LSm6

Gene: LSM6
Organism: Homo sapiens
Interactions: 77
UniProt ID: P62312

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

974349

LSM5
U6 snRNA-associated Sm-like protein LSm5

10

20

High-throughput

0.978

High

926162

ICLN
Methylosome subunit pICln

8

8

High-throughput

0.974

High

974228

LSM3
U6 snRNA-associated Sm-like protein LSm3

6

20

High-throughput

0.956

High

974347

LSM2
U6 snRNA-associated Sm-like protein LSm2

6

19

High-throughput

0.949

High

974350

LSM4
U6 snRNA-associated Sm-like protein LSm4

6

19

Small-scale

0.940

High

974308

SMD2
Small nuclear ribonucleoprotein Sm D2

5

20

High-throughput

0.935

High

974346

LSM7
U6 snRNA-associated Sm-like protein LSm7

5

20

High-throughput

0.928

High

178012

LSM1
U6 snRNA-associated Sm-like protein LSm1

5

20

High-throughput

0.925

High

974317

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

5

20

High-throughput

0.925

High

974324

PATL1
Protein PAT1 homolog 1

5

9

High-throughput

0.924

High

344527

LSM8
U6 snRNA-associated Sm-like protein LSm8

4

20

High-throughput

0.902

High

215066

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

4

10

High-throughput

0.892

High

973871

RUXF
Small nuclear ribonucleoprotein F

3

17

High-throughput

0.870

High

167077

GEMI2
Gem-associated protein 2

2

4

High-throughput

0.811

High

286443

WBP4
WW domain-binding protein 4

2

7

High-throughput

0.811

High

574204

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

15

High-throughput

0.811

High

973681

RUXE
Small nuclear ribonucleoprotein E

2

17

High-throughput

0.811

High

974307

SMD1
Small nuclear ribonucleoprotein Sm D1

2

19

High-throughput

0.811

High

974333

LSM10
U7 snRNA-associated Sm-like protein LSm10

2

17

High-throughput

0.811

High

209237

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

4

20

High-throughput

0.699

High

480080

RU1C
U1 small nuclear ribonucleoprotein C

1

7

High-throughput

0.691

High

974107

RUXG
Small nuclear ribonucleoprotein G

1

20

High-throughput

0.691

High

974310

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

16

High-throughput

0.691

High

974323

MEPCE
7SK snRNA methylphosphate capping enzyme

3

6

High-throughput

0.667

High

974332

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

3

10

High-throughput

0.662

High

974338

RIOK1
Serine/threonine-protein kinase RIO1

3

4

High-throughput

0.662

High

974341

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

3

3

High-throughput

0.662

High

974342

COPRS
Coordinator of PRMT5 and differentiation stimulator

3

2

High-throughput

0.662

High

974344

AKA7G
A-kinase anchor protein 7 isoform gamma

3

7

High-throughput

0.650

High

140211

SDCB1
Syntenin-1

3

0

High-throughput

0.646

High

162529

ANM5
Protein arginine N-methyltransferase 5

2

4

High-throughput

0.628

High

974329

ZN511
Zinc finger protein 511

2

1

High-throughput

0.628

High

974337

MEP50
Methylosome protein WDR77

2

17

High-throughput

0.628

High

974316

RBM39
RNA-binding protein 39

2

11

High-throughput

0.611

High

974348

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

7

Small-scale

0.611

High

212195

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

2

High-throughput

0.536

High

321486

PRP6
Pre-mRNA-processing factor 6

1

20

High-throughput

0.536

High

477979

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

483065

CLCA
Clathrin light chain A

1

5

High-throughput

0.536

High

483321

CLCB
Clathrin light chain B

1

5

High-throughput

0.536

High

541925

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

799832

COIL
Coilin

1

3

High-throughput

0.536

High

872159

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.536

High

938330

NH2L1
NHP2-like protein 1

1

1

High-throughput

0.536

High

974311

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

974312

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

7

High-throughput

0.536

High

974314

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

3

High-throughput

0.536

High

974318

SF3A1
Splicing factor 3A subunit 1

1

7

High-throughput

0.536

High

974320

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

High-throughput

0.536

High

974339

RBM42
RNA-binding protein 42

1

13

High-throughput

0.536

High

974340

DDX23
Probable ATP-dependent RNA helicase DDX23

1

10

High-throughput

0.536

High

974343

IL36B
Interleukin-36 beta

1

0

High-throughput

0.513

High

974321

SMN
Survival motor neuron protein

1

7

Small-scale

0.501

High

974335

TMCO6
Transmembrane and coiled-coil domain-containing protein 6

1

2

High-throughput

0.489

High

878252

DPOD2
DNA polymerase delta subunit 2

1

0

High-throughput

0.486

High

974336

MCRS1
Microspherule protein 1

1

0

High-throughput

0.486

High

974313

TADBP
TAR DNA-binding protein 43

1

6

Small-scale

0.481

High

421864

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

216241

PPIH
Peptidyl-prolyl cis-trans isomerase H

1

6

High-throughput

0.479

High

247797

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

315391

RECQ4
ATP-dependent DNA helicase Q4

1

11

High-throughput

0.479

High

371665

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

405995

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

974309

H4
Histone H4

1

4

High-throughput

0.479

High

974319

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

974322

LARP7
La-related protein 7

1

12

High-throughput

0.479

High

974325

THOC4
THO complex subunit 4

1

10

High-throughput

0.479

High

974326

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.479

High

974327

RHG18
Rho GTPase-activating protein 18

1

7

High-throughput

0.479

High

974328

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

6

Small-scale

0.479

High

974330

LS14A
Protein LSM14 homolog A

1

7

Small-scale

0.479

High

974334

DCPS
m7GpppX diphosphatase

1

3

High-throughput

0.479

High

974345

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

974315

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

974331

DPTOR
DEP domain-containing mTOR-interacting protein

1

2

Small-scale

0.437

High

886715

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

224417

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

7

High-throughput

0.407

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025