HitPredict

Interactor 1: SMD3 (P62318)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SNRPD3

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	28977470, 11756452, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0034709 - methylosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 342
+	Hs
		1410417 LSM4_HUMAN (5-84): 8.79e-35: 118: 30.86		MEP50_HUMAN (1-342): 3.04e-83: 257: 100.00
+	Hs
		974460 SMD1_HUMAN (7-94): 9.56e-33: 112: 27.27		MEP50_HUMAN (1-342): 3.04e-83: 257: 100.00
+	Hs
		1380460 LSM10_HUMAN (7-103): 1.22e-29: 105: 19.59		MEP50_HUMAN (1-342): 3.04e-83: 257: 100.00
+	Hs
		974027 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		MEP50_HUMAN (1-342): 3.04e-83: 257: 100.00
+	Hs
		974805 SMD3_HUMAN (1-126): 1.78e-42: 137: 100.00		FBXW7_HUMAN (107-336): 3.75e-59: 204: 18.10
+	Hs
		974440 SMD1_HUMAN (7-94): 9.56e-33: 112: 27.27		FBXW7_HUMAN (107-336): 3.75e-59: 204: 18.10
+	Hs
		964813 SMD3_HUMAN (1-126): 1.78e-42: 137: 100.00		WDR5_HUMAN (162-339): 8.32e-50: 171: 21.79
+	Hs
		965372 LSM4_HUMAN (5-84): 8.79e-35: 118: 30.86		WDR5_HUMAN (162-339): 8.32e-50: 171: 21.79
+	Hs
		964811 SMD1_HUMAN (7-94): 9.56e-33: 112: 27.27		WDR5_HUMAN (162-339): 8.32e-50: 171: 21.79
+	Hs
		965353 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		WDR5_HUMAN (162-339): 8.32e-50: 171: 21.79
+	Hs
		964810 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		WDR5_HUMAN (162-339): 8.32e-50: 171: 21.79
+	Hs
		974811 SMD3_HUMAN (1-126): 1.78e-42: 137: 100.00		SNR40_HUMAN (247-341): 2.17e-15: 78.2: 14.43
+	Hs
		209239 SMD3_HUMAN (1-126): 1.78e-42: 137: 100.00		PRP4_HUMAN (253-341): 3.59e-10: 62.8: 13.40
+	Hs
		1387663 LSM4_HUMAN (5-84): 8.79e-35: 118: 30.86		SNR40_HUMAN (247-341): 2.17e-15: 78.2: 14.43
+	Hs
		974444 SMD1_HUMAN (7-94): 9.56e-33: 112: 27.27		SNR40_HUMAN (247-341): 2.17e-15: 78.2: 14.43
+	Hs
		1387658 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		SNR40_HUMAN (247-341): 2.17e-15: 78.2: 14.43
+	Hs
		209361 LSM4_HUMAN (5-84): 8.79e-35: 118: 30.86		PRP4_HUMAN (253-341): 3.59e-10: 62.8: 13.40
+	Hs
		974009 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		SNR40_HUMAN (247-341): 2.17e-15: 78.2: 14.43
+	Hs
		209358 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		PRP4_HUMAN (253-341): 3.59e-10: 62.8: 13.40
+	Hs
		209234 RUXF_HUMAN (1-72): 4.66e-28: 100: 24.66		PRP4_HUMAN (253-341): 3.59e-10: 62.8: 13.40