HitPredict

Interactor 1: PLRG1 (O43660)
Pleiotropic regulator 1
Gene: PLRG1

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 514 Hs			1 465
+	Hs
		228612 TBL1R_HUMAN (191-514): 2.22e-85: 274: 19.20		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		229098 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228868 NLE1_HUMAN (49-357): 5.8e-65: 220: 17.74		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228315 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227054 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226765 LIS1_HUMAN (38-318): 4.42e-54: 189: 17.55		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228276 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228555 KTNB1_HUMAN (302-489): 8.04e-18: 88.6: 30.53		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		196917 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		1219356 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58
+	Hs
		1377165 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67
+	Hs
		1281514 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67
+	Hs
		476595 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476181 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475563 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476151 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1092188 GPLPC_ARATH (180-315): 3.98e-22: 98.9: 23.08		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		196947 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47