HitPredict

Interactor 1: WDR59 (Q03897)
Maintenance of telomere capping protein 5 (SEH-associated protein 3)
Gene: MTC5

Interactor 2: SEC13 (Q04491)
Protein transport protein SEC13
Gene: SEC13

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	10688190, 25073740, 37968396, 21454883
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005774 - vacuolar membrane GO:0035859 - Seh1-associated complex GO:1903432 - regulation of TORC1 signaling GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1148 Sc			1 297
+	Sc
		858400 WDR59_YEAST (1-1148): 0: 831: 100.00		SEH1_YEAST (1-293): 1.56e-68: 218: 21.97
+	Hs
		1289586 WDR24_HUMAN (3-175): 8.12e-21: 100: 13.74		SEH1_HUMAN (4-293): 9.65e-93: 280: 28.04
+	Sc
		784390 COPB2_YEAST (2-364): 3.6e-36: 150: 11.14		SEH1_YEAST (1-293): 1.56e-68: 218: 21.97
+	Hs
		725410 COPB2_HUMAN (2-228): 3.52e-46: 182: 14.04		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Hs
		792949 LIS1_HUMAN (154-488): 3.85e-46: 173: 12.24		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Ce
		954080 LIN53_CAEEL (23-187): 2.27e-24: 109: 16.02		SEC13_CAEEL (3-297): 2.85e-70: 221: 37.79
+	Hs
		1240442 POC1B_HUMAN (54-533): 3.48e-70: 244: 15.35		POC1A_HUMAN (1-83): 2.42e-15: 77.4: 30.12
+	Sc
		630844 NLE1_YEAST (199-547): 4.86e-52: 193: 9.77		NLE1_YEAST (2-185): 6.26e-32: 125: 18.39
+	Sp
		999842 TUP12_SCHPO (149-471): 2.17e-42: 167: 9.76		TUP11_SCHPO (1-135): 3.94e-34: 132: 21.38
+	Hs
		792935 LIS1_HUMAN (154-488): 3.85e-46: 173: 12.24		LIS1_HUMAN (133-297): 3.98e-32: 124: 16.97
+	Hs
		282871 CIAO1_HUMAN (164-399): 2.77e-26: 113: 13.69		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Hs
		903551 NLE1_HUMAN (388-681): 3.05e-24: 109: 7.47		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Hs
		903418 FBXW7_HUMAN (230-532): 4.61e-19: 95: 5.83		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Hs
		282837 COPB2_HUMAN (2-228): 3.52e-46: 182: 14.04		CIAO1_HUMAN (195-287): 5.06e-11: 64.3: 28.72
+	Hs
		282843 LIS1_HUMAN (154-488): 3.85e-46: 173: 12.24		CIAO1_HUMAN (195-287): 5.06e-11: 64.3: 28.72
+	Mm
		925836 LIS1_MOUSE (384-591): 1.68e-23: 106: 7.01		LIS1_MOUSE (133-297): 3.31e-32: 124: 16.97
+	Ce
		954090 LIN53_CAEEL (23-187): 2.27e-24: 109: 16.02		LIS1_CAEEL (1-85): 3.79e-15: 77.1: 18.82
+	Hs
		282789 CIAO1_HUMAN (164-399): 2.77e-26: 113: 13.69		CIAO1_HUMAN (195-287): 5.06e-11: 64.3: 28.72
+	Hs
		878236 WDR24_HUMAN (3-175): 8.12e-21: 100: 13.74		SEC13_HUMAN (3-104): 2.32e-09: 59.3: 25.46