HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 406
+	Hs
		754812 H2B1B_HUMAN (1-126): 1.53e-53: 165: 97.62		RING1_HUMAN (1-406): 2.02e-114: 342: 100.00
+	Hs
		1163160 H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21		RING2_HUMAN (8-406): 4.92e-100: 302: 54.25
+	Hs
		981037 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		RING2_HUMAN (8-406): 4.92e-100: 302: 54.25
+	Hs
		754955 H2B1B_HUMAN (1-126): 1.53e-53: 165: 97.62		RING2_HUMAN (8-406): 4.92e-100: 302: 54.25
+	Hs
		1323962 H2B3B_HUMAN (1-126): 8.33e-52: 161: 95.24		RING2_HUMAN (8-406): 4.92e-100: 302: 54.25
+	Hs
		765336 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		BMI1_HUMAN (31-378): 4.08e-63: 207: 14.16
+	Hs
		765567 H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21		BMI1_HUMAN (31-378): 4.08e-63: 207: 14.16
+	Hs
		754739 H2B1B_HUMAN (1-126): 1.53e-53: 165: 97.62		BMI1_HUMAN (31-378): 4.08e-63: 207: 14.16
+	Hs
		765297 H2B1D_HUMAN (1-126): 3.25e-53: 164: 99.21		BMI1_HUMAN (31-378): 4.08e-63: 207: 14.16
+	Hs
		623504 H2B1N_HUMAN (1-126): 3.01e-53: 164: 99.21		RO52_HUMAN (33-392): 4.69e-43: 158: 13.14
+	Hs
		1163165 H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21		BARD1_HUMAN (4-335): 2.57e-39: 151: 13.35
+	Hs
		766093 H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21		PCGF2_HUMAN (31-377): 1.45e-41: 151: 14.37
+	Hs
		981044 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		BARD1_HUMAN (4-335): 2.57e-39: 151: 13.35
+	Hs
		754957 H2B1B_HUMAN (1-126): 1.53e-53: 165: 97.62		BARD1_HUMAN (4-335): 2.57e-39: 151: 13.35
+	Hs
		1163177 H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21		PCGF1_HUMAN (25-133): 3.55e-40: 145: 25.00
+	Hs
		981055 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		PCGF1_HUMAN (25-133): 3.55e-40: 145: 25.00
+	Hs
		798952 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		BRCA1_HUMAN (33-361): 4.26e-35: 139: 15.63
+	Hs
		799164 H2B2E_HUMAN (1-126): 5.64e-54: 166: 99.21		BRCA1_HUMAN (33-361): 4.26e-35: 139: 15.63
+	Hs
		754745 H2B1B_HUMAN (1-126): 1.53e-53: 165: 97.62		BRCA1_HUMAN (33-361): 4.26e-35: 139: 15.63
+	Mm
		1225794 H2B2E_MOUSE (1-126): 1.09e-52: 163: 96.03		CHFR_MOUSE (24-278): 1.38e-34: 137: 15.69