HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: VRK1 (Q99986)
Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1)
Gene: VRK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	18617507
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm and 2 others more... GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 396
+	Hs
		1144991 RAB35_HUMAN (1-188): 1.33e-82: 245: 29.47		VRK2_HUMAN (10-396): 2.99e-125: 372: 47.03
+	Hs
		981571 RAN_HUMAN (1-216): 1.48e-79: 238: 100.00		VRK2_HUMAN (10-396): 2.99e-125: 372: 47.03
+	Hs
		976387 RB11A_HUMAN (4-208): 4.29e-78: 235: 26.67		VRK2_HUMAN (10-396): 2.99e-125: 372: 47.03
+	Hs
		1144977 RAB35_HUMAN (1-188): 1.33e-82: 245: 29.47		MARK2_HUMAN (2-358): 6.83e-106: 331: 14.44
+	Hs
		692066 RAB35_HUMAN (1-188): 1.33e-82: 245: 29.47		MARK3_HUMAN (3-341): 2.34e-105: 329: 14.62
+	Hs
		877082 RAB1A_HUMAN (1-196): 2.37e-81: 242: 28.00		KC1D_HUMAN (29-392): 1.2e-109: 329: 24.40
+	Hs
		976359 RB11A_HUMAN (4-208): 4.29e-78: 235: 26.67		MARK2_HUMAN (2-358): 6.83e-106: 331: 14.44
+	Hs
		692033 RB11A_HUMAN (4-208): 4.29e-78: 235: 26.67		MARK3_HUMAN (3-341): 2.34e-105: 329: 14.62
+	Hs
		1145205 RAB35_HUMAN (1-188): 1.33e-82: 245: 29.47		KC1G3_HUMAN (10-393): 5.94e-100: 306: 21.94
+	Hs
		976709 RB11A_HUMAN (4-208): 4.29e-78: 235: 26.67		KC1G3_HUMAN (10-393): 5.94e-100: 306: 21.94
+	Hs
		901370 RAB7A_HUMAN (8-166): 7.47e-29: 108: 33.13		VRK2_HUMAN (10-396): 2.99e-125: 372: 47.03
+	Hs
		630868 RAB4A_HUMAN (11-169): 1.54e-27: 105: 34.57		VRK2_HUMAN (10-396): 2.99e-125: 372: 47.03
+	Hs
		981572 RAN_HUMAN (1-216): 1.48e-79: 238: 100.00		VRK3_HUMAN (21-329): 4.15e-62: 208: 36.08
+	Sc
		656406 GSP1_YEAST (1-214): 1.88e-96: 281: 80.56		KC11_YEAST (37-389): 3.76e-31: 126: 27.45
+	Sc
		376271 YPT1_YEAST (4-177): 6.94e-83: 246: 28.25		KC11_YEAST (37-389): 3.76e-31: 126: 27.45