Protein: VRK3
Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3)

Gene: VRK3
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q8IV63

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1308471

ZN524
Zinc finger protein 524

3

1

High-throughput

0.861

High

1036852

SP4
Transcription factor Sp4

2

0

High-throughput

0.770

High

1035006

KPCE
Protein kinase C epsilon type

1

14

High-throughput

0.691

High

1107888

SQSTM
Sequestosome-1

1

5

High-throughput

0.691

High

1130775

RRP5
Protein RRP5 homolog

1

5

High-throughput

0.691

High

981572

RAN
GTP-binding nuclear protein Ran

1

10

Small-scale

0.681

High

1308494

NR2E1
Nuclear receptor subfamily 2 group E member 1

3

11

High-throughput

0.667

High

920095

PLK1
Serine/threonine-protein kinase PLK1

1

19

High-throughput

0.656

High

995120

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.656

High

1308481

SCRT1
Transcriptional repressor scratch 1

1

2

High-throughput

0.618

High

1308492

ANR50
Ankyrin repeat domain-containing protein 50

1

1

High-throughput

0.618

High

214866

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

2

High-throughput

0.618

High

401102

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

461675

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

462501

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

6

High-throughput

0.618

High

485246

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

10

High-throughput

0.618

High

573856

CCNB1
G2/mitotic-specific cyclin-B1

1

5

High-throughput

0.618

High

620459

NUCL
Nucleolin

1

1

High-throughput

0.618

High

650844

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

9

High-throughput

0.618

High

910577

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

High-throughput

0.618

High

996495

ACTS
Actin, alpha skeletal muscle

1

6

High-throughput

0.618

High

1153060

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

17

High-throughput

0.618

High

1158413

CDC37
Hsp90 co-chaperone Cdc37

1

3

High-throughput

0.618

High

1290069

THOC4
THO complex subunit 4

1

1

High-throughput

0.618

High

1308459

VRK3
Serine/threonine-protein kinase VRK3

1

15

High-throughput

0.618

High

1308469

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

16

High-throughput

0.618

High

1308472

LMTK3
Serine/threonine-protein kinase LMTK3

1

20

High-throughput

0.618

High

1308485

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.618

High

1308487

TLR9
Toll-like receptor 9

1

1

High-throughput

0.618

High

1308490

UBQL2
Ubiquilin-2

1

5

High-throughput

0.618

High

414150

P53
Cellular tumor antigen p53

2

6

High-throughput

0.584

High

979938

H4
Histone H4

2

5

High-throughput

0.584

High

1017003

H33
Histone H3.3

2

11

High-throughput

0.584

High

396457

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

1308462

TXND5
Thioredoxin domain-containing protein 5

2

3

High-throughput

0.558

High

959613

MAX
Protein max

1

9

High-throughput

0.554

High

549335

SRF
Serum response factor

1

1

High-throughput

0.536

High

571620

IRF2
Interferon regulatory factor 2

1

1

High-throughput

0.536

High

601760

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

915468

HMGA2
High mobility group protein HMGI-C

1

3

High-throughput

0.536

High

960479

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.536

High

1048224

EMX2
Homeobox protein EMX2

1

3

High-throughput

0.536

High

1308467

EZH1
Histone-lysine N-methyltransferase EZH1

1

1

High-throughput

0.536

High

1308484

FOXP1
Forkhead box protein P1

1

6

High-throughput

0.536

High

1308486

TF7L2
Transcription factor 7-like 2

1

5

High-throughput

0.536

High

1308491

FOXD3
Forkhead box protein D3

1

3

High-throughput

0.536

High

329153

RCBT2
RCC1 and BTB domain-containing protein 2

1

5

High-throughput

0.515

High

1233706

TWF2
Twinfilin-2

1

2

High-throughput

0.515

High

166167

AIM2
Interferon-inducible protein AIM2

1

0

High-throughput

0.513

High

1308466

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.513

High

1308483

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

185836

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

1308493

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

1308474

SORT
Sortilin

1

1

High-throughput

0.489

High

207582

DHX15
ATP-dependent RNA helicase DHX15

1

3

High-throughput

0.479

High

285687

BAF
Barrier-to-autointegration factor

1

3

High-throughput

0.479

High

428441

RLA2
Large ribosomal subunit protein P2

1

3

High-throughput

0.479

High

447193

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

457536

TBB5
Tubulin beta chain

1

12

High-throughput

0.479

High

474798

VIME
Vimentin

1

5

High-throughput

0.479

High

475395

RS17
Small ribosomal subunit protein eS17

1

1

High-throughput

0.479

High

487498

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

521792

H14
Histone H1.4

1

6

High-throughput

0.479

High

532737

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

537462

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

552305

ADT3
ADP/ATP translocase 3

1

9

High-throughput

0.479

High

558252

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

559410

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.479

High

565962

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

600852

HSP76
Heat shock 70 kDa protein 6

1

10

High-throughput

0.479

High

606898

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

610756

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.479

High

615859

RL17
Large ribosomal subunit protein uL22

1

3

High-throughput

0.479

High

660111

COF1
Cofilin-1

1

2

High-throughput

0.479

High

681683

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.479

High

686252

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.479

High

691214

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

716904

RL12
Large ribosomal subunit protein uL11

1

1

High-throughput

0.479

High

761749

HSP74
Heat shock 70 kDa protein 4

1

12

High-throughput

0.479

High

764877

CTNB1
Catenin beta-1

1

8

High-throughput

0.479

High

851783

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.479

High

859640

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.479

High

872499

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.479

High

876050

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.479

High

879251

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

884461

PCY1A
Choline-phosphate cytidylyltransferase A

1

2

High-throughput

0.479

High

894881

EMD
Emerin

1

3

High-throughput

0.479

High

898717

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.479

High

926202

ICLN
Methylosome subunit pICln

1

1

High-throughput

0.479

High

954187

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

959849

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

965766

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

5

High-throughput

0.479

High

967486

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

967839

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

High-throughput

0.479

High

968367

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

10

High-throughput

0.479

High

969647

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.479

High

972477

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

972902

RS18
Small ribosomal subunit protein uS13

1

2

High-throughput

0.479

High

978600

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

982725

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

985234

RL10A
Large ribosomal subunit protein uL1

1

4

High-throughput

0.479

High

985756

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.479

High

997411

TBB4B
Tubulin beta-4B chain

1

12

High-throughput

0.479

High

1007122

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.479

High

1027574

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

High-throughput

0.479

High

1036764

DSG1
Desmoglein-1

1

3

High-throughput

0.479

High

1037548

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.479

High

1045477

TF65
Transcription factor p65

1

13

High-throughput

0.479

High

1057205

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.479

High

1130010

KCTD2
BTB/POZ domain-containing protein KCTD2

1

12

High-throughput

0.479

High

1163038

H2B2E
Histone H2B type 2-E

1

11

High-throughput

0.479

High

1308460

CMYA5
Cardiomyopathy-associated protein 5

1

18

High-throughput

0.479

High

1308461

KCD17
BTB/POZ domain-containing protein KCTD17

1

13

High-throughput

0.479

High

1308464

BICD2
Protein bicaudal D homolog 2

1

11

High-throughput

0.479

High

1308468

JARD2
Protein Jumonji

1

1

High-throughput

0.479

High

1308475

ATX2
Ataxin-2

1

2

High-throughput

0.479

High

1308477

H2A1J
Histone H2A type 1-J

1

4

High-throughput

0.479

High

1308478

H2B1M
Histone H2B type 1-M

1

11

High-throughput

0.479

High

1308479

TBA1C
Tubulin alpha-1C chain

1

20

High-throughput

0.479

High

1308482

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

9

High-throughput

0.479

High

1308488

BCLF1
Bcl-2-associated transcription factor 1

1

2

High-throughput

0.479

High

1308489

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

6

High-throughput

0.479

High

1308495

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

428186

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.458

High

629952

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

688060

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.458

High

860827

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.458

High

974420

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.458

High

991208

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

0

High-throughput

0.458

High

1258294

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

1308463

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

1

0

High-throughput

0.458

High

1308470

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1308473

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.458

High

1308480

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

1

0

High-throughput

0.458

High

1308496

SPIN1
Spindlin-1

1

0

High-throughput

0.458

High

430105

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

1308476

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

106224

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1280873

CNTRL
Centriolin

1

5

High-throughput

0.437

High

1308465

RBCC1
RB1-inducible coiled-coil protein 1

1

11

High-throughput

0.437

High

1258128

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.318

High

169192

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

488062

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

1244432

CP087
UPF0547 protein C16orf87

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025