Protein: MED16
Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)

Gene: MED16
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9Y2X0

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006366 - transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1347859

MED29
Mediator of RNA polymerase II transcription subunit 29

4

1

High-throughput

0.903

High

1356919

MED23
Mediator of RNA polymerase II transcription subunit 23

4

1

Small-scale

0.900

High

1174979

MED25
Mediator of RNA polymerase II transcription subunit 25

4

0

Small-scale

0.836

High

1301102

MED15
Mediator of RNA polymerase II transcription subunit 15

3

1

Small-scale

0.827

High

265376

MED24
Mediator of RNA polymerase II transcription subunit 24

3

0

Small-scale

0.803

High

1305150

DNJC7
DnaJ homolog subfamily C member 7

2

0

High-throughput

0.770

High

826379

CDK8
Cyclin-dependent kinase 8

13

3

Small-scale

0.761

High

1312310

MED10
Mediator of RNA polymerase II transcription subunit 10

7

1

Small-scale

0.745

High

1271473

KAT2A
Histone acetyltransferase KAT2A

2

2

Small-scale

0.737

High

1314891

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

48752

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.720

High

1312774

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.718

High

1281497

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.716

High

1076219

MED1
Mediator of RNA polymerase II transcription subunit 1

7

0

Small-scale

0.714

High

206662

MED7
Mediator of RNA polymerase II transcription subunit 7

4

1

High-throughput

0.699

High

1334016

MED20
Mediator of RNA polymerase II transcription subunit 20

4

1

High-throughput

0.699

High

1342960

MED4
Mediator of RNA polymerase II transcription subunit 4

4

1

High-throughput

0.699

High

1274368

MED12
Mediator of RNA polymerase II transcription subunit 12

4

1

High-throughput

0.694

High

624535

CCNC
Cyclin-C

4

1

High-throughput

0.686

High

1328962

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.684

High

1037116

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

High-throughput

0.674

High

1346451

MED17
Mediator of RNA polymerase II transcription subunit 17

3

1

High-throughput

0.667

High

1347157

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

370766

ESR1
Estrogen receptor

3

5

Small-scale

0.660

High

225437

MED14
Mediator of RNA polymerase II transcription subunit 14

3

1

Small-scale

0.656

High

1269987

ESR2
Estrogen receptor beta

3

5

Small-scale

0.641

High

245117

BRD4
Bromodomain-containing protein 4

3

1

Small-scale

0.640

High

313479

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.638

High

1074738

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.638

High

270543

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.611

High

1291855

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.611

High

1349551

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

1377455

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.602

High

1355587

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.601

High

297947

ST65G
STAGA complex 65 subunit gamma

1

0

Small-scale

0.586

High

815308

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.586

High

1132761

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.586

High

1158934

MED27
Mediator of RNA polymerase II transcription subunit 27

2

0

High-throughput

0.585

High

509997

VDR
Vitamin D3 receptor

2

2

Small-scale

0.584

High

1293712

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

Small-scale

0.584

High

500452

THA
Thyroid hormone receptor alpha

2

4

Small-scale

0.571

High

1146984

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.553

High

1377456

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.546

High

1077844

CEBPE
CCAAT/enhancer-binding protein epsilon

1

1

High-throughput

0.541

High

1331682

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.517

High

117869

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.513

High

160868

AURKA
Aurora kinase A

1

0

High-throughput

0.513

High

207131

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

454782

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

548343

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.513

High

677060

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

913983

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

1160908

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

782700

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

Small-scale

0.501

High

554533

GATA1
Erythroid transcription factor

1

2

Small-scale

0.500

High

348297

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.480

High

1377457

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

266456

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

387780

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

487862

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

950337

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.479

High

1078703

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.479

High

1078783

SMAD1
Mothers against decapentaplegic homolog 1

1

2

Small-scale

0.479

High

1174790

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

2

High-throughput

0.479

High

1206168

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

1

High-throughput

0.479

High

161742

GAK
Cyclin-G-associated kinase

1

0

High-throughput

0.458

High

266513

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

299498

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

652664

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

935406

H31
Histone H3.1

1

0

Small-scale

0.458

High

941602

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

964469

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

981145

ACVR1
Activin receptor type-1

1

0

High-throughput

0.458

High

1048291

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

1173791

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1236589

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1270734

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1299710

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1306558

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1332200

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1354051

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.458

High

73050

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91319

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1357016

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

375124

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

1301422

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1303878

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

831826

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

1235472

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

0

High-throughput

0.282

High

276291

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.279

Low

324134

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1062716

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

1299277

OPALI
Opalin

1

0

High-throughput

0.279

Low

1302890

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

329059

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.249

Low

385763

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

856586

EFNB2
Ephrin-B2

1

0

High-throughput

0.249

Low

1135371

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.249

Low

1350511

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024