Protein: VRK2
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)

Gene: VRK2
Organism: Homo sapiens
Interactions: 237
UniProt ID: Q86Y07

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955346

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.793

High

213958

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

8

Small-scale

0.789

High

1038318

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

19

Small-scale

0.789

High

375683

RASK
GTPase KRas

2

20

High-throughput

0.754

High

981571

RAN
GTP-binding nuclear protein Ran

1

15

Small-scale

0.724

High

1294478

FAF2
FAS-associated factor 2

4

3

High-throughput

0.694

High

162009

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

19

Small-scale

0.691

High

295603

CIB2
Calcium and integrin-binding family member 2

1

20

High-throughput

0.691

High

572940

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.691

High

638464

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.691

High

853707

MK08
Mitogen-activated protein kinase 8

1

20

Small-scale

0.691

High

854145

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.691

High

1104432

ILK
Scaffold protein ILK

1

10

High-throughput

0.691

High

1149120

SF3A1
Splicing factor 3A subunit 1

1

2

High-throughput

0.691

High

385923

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

5

High-throughput

0.676

High

212443

SPIT2
Kunitz-type protease inhibitor 2

3

9

High-throughput

0.667

High

1294530

SRPRB
Signal recognition particle receptor subunit beta

3

8

High-throughput

0.667

High

1294449

KSR1
Kinase suppressor of Ras 1

1

20

Small-scale

0.665

High

920090

PLK1
Serine/threonine-protein kinase PLK1

1

19

Small-scale

0.647

High

944921

TMPS3
Transmembrane protease serine 3

2

7

High-throughput

0.628

High

1294470

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

6

High-throughput

0.628

High

66446

ASB14
Ankyrin repeat and SOCS box protein 14

1

2

High-throughput

0.618

High

165979

FFAR1
Free fatty acid receptor 1

1

3

High-throughput

0.618

High

182639

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.618

High

711566

NK3R
Neuromedin-K receptor

1

3

High-throughput

0.618

High

1291834

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

2

High-throughput

0.618

High

1294531

GPR45
Probable G-protein coupled receptor 45

1

7

High-throughput

0.618

High

126680

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

157575

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.618

High

179619

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

20

High-throughput

0.618

High

401091

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

439772

INSR
Insulin receptor

1

20

High-throughput

0.618

High

464001

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.618

High

466340

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581149

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

605742

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

16

High-throughput

0.618

High

630562

RAB3B
Ras-related protein Rab-3B

1

5

High-throughput

0.618

High

631326

RAB5A
Ras-related protein Rab-5A

1

11

High-throughput

0.618

High

710725

EPHA8
Ephrin type-A receptor 8

1

17

High-throughput

0.618

High

901370

RAB7A
Ras-related protein Rab-7a

1

13

High-throughput

0.618

High

901915

RAB9A
Ras-related protein Rab-9A

1

13

High-throughput

0.618

High

910120

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

953544

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962234

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962779

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

976387

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.618

High

988499

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1004116

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.618

High

1015573

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1125524

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

8

High-throughput

0.618

High

1151761

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1156987

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1251333

DJC14
DnaJ homolog subfamily C member 14

1

4

High-throughput

0.618

High

1294461

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.618

High

1294472

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1294477

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.618

High

1294484

DNJC1
DnaJ homolog subfamily C member 1

1

6

High-throughput

0.618

High

1294499

DJC25
DnaJ homolog subfamily C member 25

1

3

High-throughput

0.618

High

1294501

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1294502

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1294504

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1294519

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.618

High

1294521

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1294525

DJC16
DnaJ homolog subfamily C member 16

1

7

High-throughput

0.618

High

417553

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.611

High

698844

CALX
Calnexin

2

4

High-throughput

0.611

High

1081280

Q0VAB0
Thromboxane A2 receptor

1

3

High-throughput

0.594

High

1106349

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

13

Small-scale

0.586

High

418249

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.585

High

540542

LAMP1
Lysosome-associated membrane glycoprotein 1

2

12

High-throughput

0.584

High

1294455

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1294510

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.580

High

1294479

DTBP1
Dysbindin

1

4

Small-scale

0.578

High

396450

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

414142

P53
Cellular tumor antigen p53

1

9

Small-scale

0.561

High

951245

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

640525

TA2R
Thromboxane A2 receptor

1

2

High-throughput

0.555

High

783013

CXA5
Gap junction alpha-5 protein

2

8

High-throughput

0.553

High

1108949

AQP6
Aquaporin-6

2

2

High-throughput

0.553

High

630868

RAB4A
Ras-related protein Rab-4A

1

11

High-throughput

0.553

High

845709

MUC18
Cell surface glycoprotein MUC18

1

7

High-throughput

0.553

High

900899

RAB5C
Ras-related protein Rab-5C

1

11

High-throughput

0.553

High

945034

RAB25
Ras-related protein Rab-25

1

7

High-throughput

0.553

High

1144991

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.553

High

1294451

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.553

High

1294456

DJC22
DnaJ homolog subfamily C member 22

1

1

High-throughput

0.553

High

329152

RCBT2
RCC1 and BTB domain-containing protein 2

1

5

High-throughput

0.536

High

391327

FRIL
Ferritin light chain

1

6

High-throughput

0.536

High

547327

CP19A
Aromatase

1

2

High-throughput

0.536

High

595072

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

5

High-throughput

0.536

High

607948

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.536

High

750565

CP2CI
Cytochrome P450 2C18

1

3

High-throughput

0.536

High

845070

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

1085339

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

14

High-throughput

0.536

High

1185813

PTHD3
Patched domain-containing protein 3

1

3

High-throughput

0.536

High

1294471

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

4

High-throughput

0.536

High

1294495

TMED9
Transmembrane emp24 domain-containing protein 9

1

2

High-throughput

0.536

High

1294506

CP26B
Cytochrome P450 26B1

1

2

High-throughput

0.536

High

1294523

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

2

Small-scale

0.536

High

1294532

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

820682

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.517

High

1215249

SL9C2
Sodium/hydrogen exchanger 11

1

5

High-throughput

0.514

High

480210

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

505177

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

813149

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

1126318

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1168739

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

1203710

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1294464

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1294465

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

1294468

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.513

High

1294475

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1294494

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

High-throughput

0.513

High

185830

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

610753

TCPA
T-complex protein 1 subunit alpha

1

2

Small-scale

0.501

High

799966

COIL
Coilin

1

1

Small-scale

0.501

High

899466

TCPD
T-complex protein 1 subunit delta

1

2

Small-scale

0.501

High

983873

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.501

High

1103709

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

5

Small-scale

0.501

High

1060189

B2CL1
Bcl-2-like protein 1

1

3

Small-scale

0.500

High

216101

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

1

High-throughput

0.489

High

700794

DMB
HLA class II histocompatibility antigen, DM beta chain

1

1

High-throughput

0.489

High

880170

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.489

High

946566

EVA1C
Protein eva-1 homolog C

1

2

High-throughput

0.489

High

986909

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

7

High-throughput

0.489

High

1119651

KCNC3
Voltage-gated potassium channel KCNC3

1

7

High-throughput

0.489

High

1292756

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

1294457

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

1

High-throughput

0.489

High

1294480

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

1294481

TSN17
Tetraspanin-17

1

2

High-throughput

0.489

High

1294491

PADC1
Protease-associated domain-containing protein 1

1

4

High-throughput

0.489

High

1294512

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

1294516

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

2

High-throughput

0.489

High

1294529

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.489

High

1007120

TCPB
T-complex protein 1 subunit beta

1

4

Small-scale

0.481

High

1294463

LNX1
E3 ubiquitin-protein ligase LNX

1

18

Small-scale

0.481

High

48684

ESYT2
Extended synaptotagmin-2

1

7

High-throughput

0.479

High

173981

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.479

High

291420

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

302882

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

13

High-throughput

0.479

High

337957

CNEP1
CTD nuclear envelope phosphatase 1

1

2

High-throughput

0.479

High

372477

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

548348

CP2C9
Cytochrome P450 2C9

1

3

High-throughput

0.479

High

562189

LAMP2
Lysosome-associated membrane glycoprotein 2

1

12

High-throughput

0.479

High

604072

CXA1
Gap junction alpha-1 protein

1

8

High-throughput

0.479

High

611212

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

9

High-throughput

0.479

High

634510

LMNB1
Lamin-B1

1

5

High-throughput

0.479

High

715657

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

837705

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

880600

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.479

High

894877

EMD
Emerin

1

3

High-throughput

0.479

High

903994

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

975108

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

979929

H4
Histone H4

1

5

High-throughput

0.479

High

980898

H2B1C
Histone H2B type 1-C/E/F/G/I

1

11

High-throughput

0.479

High

984844

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

986541

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1024678

VIGLN
Vigilin

1

5

High-throughput

0.479

High

1027066

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

1058505

CKAP4
Cytoskeleton-associated protein 4

1

14

High-throughput

0.479

High

1087174

STX4
Syntaxin-4

1

5

High-throughput

0.479

High

1111595

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.479

High

1159734

OCLN
Occludin

1

5

High-throughput

0.479

High

1214520

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

4

High-throughput

0.479

High

1238727

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

1245088

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1252109

SYNE3
Nesprin-3

1

8

High-throughput

0.479

High

1276191

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1276440

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1294459

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1294467

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1294473

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

1294474

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

1294482

TECT2
Tectonic-2

1

1

High-throughput

0.479

High

1294483

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1294485

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1294486

PANX1
Pannexin-1

1

3

High-throughput

0.479

High

1294487

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

2

High-throughput

0.479

High

1294489

RMD3
Regulator of microtubule dynamics protein 3

1

3

High-throughput

0.479

High

1294492

ESYT1
Extended synaptotagmin-1

1

6

High-throughput

0.479

High

1294496

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

1294500

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.479

High

1294511

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

1294517

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1294518

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

519155

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

847591

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

1004788

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1204869

MKS3
Meckelin

1

0

High-throughput

0.458

High

1248989

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1288476

LBN
Limbin

1

0

High-throughput

0.458

High

1294450

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1294462

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1294490

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1294493

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1294497

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1294503

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1294507

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1294513

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

1294514

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1294527

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

522113

BCL2
Apoptosis regulator Bcl-2

1

3

Small-scale

0.457

High

1060102

BAX
Apoptosis regulator BAX

1

3

Small-scale

0.445

High

1294460

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.445

High

1294522

XCT
Cystine/glutamate transporter

1

3

High-throughput

0.445

High

139918

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

188927

TMPS2
Transmembrane protease serine 2

1

8

High-throughput

0.437

High

189677

STX7
Syntaxin-7

1

5

High-throughput

0.437

High

879244

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.437

High

1163369

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.437

High

1286818

TM11B
Transmembrane protease serine 11B

1

10

High-throughput

0.437

High

1293053

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1294453

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.437

High

1294509

TMPS4
Transmembrane protease serine 4

1

8

High-throughput

0.437

High

1294520

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

1294524

LAMP3
Lysosome-associated membrane glycoprotein 3

1

12

High-throughput

0.437

High

1294498

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

1294526

S27A5
Long-chain fatty acid transport protein 5

1

0

High-throughput

0.426

High

652211

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

3

High-throughput

0.407

High

1226998

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.407

High

1230821

SL9A4
Sodium/hydrogen exchanger 4

1

5

High-throughput

0.407

High

1294488

SL9A7
Sodium/hydrogen exchanger 7

1

5

High-throughput

0.407

High

1165220

F187B
Protein FAM187B

3

0

High-throughput

0.347

High

1244097

TMM88
Transmembrane protein 88

2

0

High-throughput

0.316

High

1248351

TM205
Transmembrane protein 205

2

0

High-throughput

0.316

High

1219676

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

1294452

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

1294454

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1294458

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

1294466

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1294469

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1294505

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1293605

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1294476

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1294508

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1294515

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1294528

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025