HitPredict

Interactor 1: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Interactor 2: L2GL1 (Q15334)
Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)
Gene: LLGL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	25852190, 28514442, 29491746, 31980649, 33961781, 32707033, unassigned2173, 24366813
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0045197 - establishment or maintenance of epithelial cell apical/basal polarity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 1064
+	Hs
		784012 KPCI_HUMAN (1-592): 0: 654: 69.87		L2GL1_HUMAN (1-1064): 0: 1391: 100.00
+	Mm
		973812 KPCZ_MOUSE (1-592): 0: 681: 95.61		L2GL1_MOUSE (1-1039): 0: 1350: 90.57
+	Mm
		1143282 KPCI_MOUSE (1-592): 0: 655: 69.70		L2GL1_MOUSE (1-1039): 0: 1350: 90.57
+	Hs
		983860 KPCZ_HUMAN (1-592): 0: 688: 100.00		L2GL2_HUMAN (5-979): 0: 1216: 56.97
+	Mm
		1111901 KPCI_MOUSE (1-592): 0: 655: 69.70		L2GL2_MOUSE (5-1011): 0: 1228: 55.74
+	Hs
		784030 KPCI_HUMAN (1-592): 0: 654: 69.87		L2GL2_HUMAN (5-979): 0: 1216: 56.97
+	Hs
		568673 KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06		L2GL1_HUMAN (1-1064): 0: 1391: 100.00
+	Rn
		1144332 AKT3_RAT (171-582): 3.93e-152: 447: 36.53		L2GL1_RAT (1-1039): 0: 1341: 90.38
+	Dm
		54639 APKC_DROME (3-592): 0: 615: 61.99		L2GL_DROME (1-1041): 0: 984: 35.51
+	Ce
		106868 KPC3_CAEEL (5-592): 0: 586: 54.53		G5EEI1_CAEEL (4-941): 0: 810: 20.57