HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RIF1 (Q5UIP0)
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
Gene: RIF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 2472
+	Hs
		584552 VAV_HUMAN (2-60): 7.9e-14: 71.6: 42.37		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		861112 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MAP1B_HUMAN (925-2416): 3.36e-43: 177: 10.23
+	Hs
		987735 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		RBBP6_HUMAN (1213-2173): 5.47e-27: 123: 9.31
+	Hs
		987539 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MAP1A_HUMAN (974-2348): 1.28e-22: 109: 9.80
+	Hs
		987550 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ANK2_HUMAN (1292-2406): 3.37e-18: 94.9: 9.95
+	Hs
		987754 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		RP1L1_HUMAN (867-2143): 7.08e-16: 86.8: 8.48
+	Hs
		987883 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MINT_HUMAN (982-2369): 1.35e-11: 72.9: 7.17
+	Hs
		67245 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		AN36A_HUMAN (913-2147): 3.15e-38: 160: 9.82
+	Hs
		593966 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ANK2_HUMAN (1292-2406): 3.37e-18: 94.9: 9.95
+	Hs
		463141 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		RBBP6_HUMAN (1213-2173): 5.47e-27: 123: 9.31
+	Hs
		913662 VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18		RBBP6_HUMAN (1213-2173): 5.47e-27: 123: 9.31
+	Hs
		594040 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		RP1L1_HUMAN (867-2143): 7.08e-16: 86.8: 8.48
+	Hs
		594085 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		MINT_HUMAN (982-2369): 1.35e-11: 72.9: 7.17
+	Hs
		440623 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		RP1L1_HUMAN (867-2143): 7.08e-16: 86.8: 8.48
+	Hs
		463458 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		ANK2_HUMAN (1292-2406): 3.37e-18: 94.9: 9.95
+	Hs
		913671 VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18		TITIN_HUMAN (1353-2455): 8.62e-10: 66.9: 8.12