HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1025
+	Hs
		440126 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MPRIP_HUMAN (1-1025): 9.69e-126: 410: 100.00
+	Hs
		987707 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		440154 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Hs
		773152 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH10_HUMAN (242-1024): 1.66e-21: 103: 8.45
+	Hs
		594054 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Hs
		772723 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		440118 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		776799 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH11_HUMAN (124-786): 5.18e-12: 72.4: 11.57
+	Hs
		987653 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		987734 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH14_HUMAN (595-972): 3.71e-09: 63.1: 14.89
+	Hs
		440215 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PKHA5_HUMAN (318-1019): 2.96e-36: 151: 13.24
+	Hs
		440251 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PKHA6_HUMAN (356-581): 1.7e-31: 135: 24.49
+	Hs
		440112 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MRCKA_HUMAN (418-981): 1.19e-30: 133: 12.40
+	Hs
		463129 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		440414 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		117127 J3QRU1_HUMAN (71-215): 6.6e-12: 65.8: 16.33		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		463006 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		1143227 Q96D37_HUMAN (2-60): 6.5e-14: 71.9: 42.37		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		584543 VAV_HUMAN (2-60): 7.9e-14: 71.6: 42.37		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		1154118 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		MYH14_HUMAN (595-972): 3.71e-09: 63.1: 14.89