HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 864
+	Hs
		839737 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		362393 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		EP15R_HUMAN (1-864): 2.18e-146: 455: 100.00
+	Hs
		1453438 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		EP15R_HUMAN (1-864): 2.18e-146: 455: 100.00
+	Hs
		64409 A6H8W8_HUMAN (108-216): 7.37e-13: 68.9: 18.92		EP15R_HUMAN (1-864): 2.18e-146: 455: 100.00
+	Hs
		593934 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		362198 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		72381 A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		839838 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		64403 A6H8W8_HUMAN (108-216): 7.37e-13: 68.9: 18.92		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		440426 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		987783 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		REPS2_HUMAN (14-99): 2.32e-12: 72.7: 24.42
+	Hs
		772723 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH9_HUMAN (362-572): 2.38e-11: 69.9: 15.07
+	Hs
		440112 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MRCKA_HUMAN (195-654): 3.18e-17: 89.3: 8.49
+	Hs
		1154182 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		ITSN1_HUMAN (1-556): 5.64e-32: 137: 12.77
+	Hs
		440576 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		ITSN1_HUMAN (1-556): 5.64e-32: 137: 12.77
+	Hs
		440262 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MRCKB_HUMAN (165-542): 1.38e-11: 70.8: 10.71
+	Hs
		1453434 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		ITSN2_HUMAN (2-545): 6.29e-25: 114: 13.09
+	Hs
		440414 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MYH9_HUMAN (362-572): 2.38e-11: 69.9: 15.07
+	Hs
		117127 J3QRU1_HUMAN (71-215): 6.6e-12: 65.8: 16.33		MYH9_HUMAN (362-572): 2.38e-11: 69.9: 15.07
+	Hs
		463006 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		MYH9_HUMAN (362-572): 2.38e-11: 69.9: 15.07