HitPredict

Interactor 1: FMR1 (Q06787)
Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1)
Gene: FMR1

Interactor 2: HOME3 (Q9NSC5)
Homer protein homolog 3 (Homer-3)
Gene: HOMER3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0030425 - dendrite
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 632 Hs			1 361
+	Mm
		729582 FMR1_MOUSE (1-632): 0: 1063: 93.99		HOME3_MOUSE (1-361): 5.75e-91: 278: 88.37
+	Hs
		988855 FMR1_HUMAN (1-632): 0: 1106: 100.00		CACO2_HUMAN (101-339): 6.54e-37: 140: 18.18
+	Hs
		787900 FMR1_HUMAN (1-632): 0: 1106: 100.00		EPS15_HUMAN (78-327): 1.5e-16: 83.1: 13.31
+	Mm
		1207084 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		HOME3_MOUSE (1-361): 5.75e-91: 278: 88.37
+	Hs
		843931 FXR1_HUMAN (1-334): 0: 604: 73.95		HOME3_HUMAN (1-361): 2.61e-97: 294: 100.00
+	Hs
		843930 FXR1_HUMAN (1-334): 0: 604: 73.95		HOME2_HUMAN (4-357): 6.53e-96: 291: 45.35
+	Mm
		1141841 FXR1_MOUSE (1-334): 0: 596: 73.65		EP15R_MOUSE (78-353): 1.02e-52: 189: 14.44
+	Hs
		843951 FXR1_HUMAN (1-334): 0: 604: 73.95		EVL_HUMAN (4-178): 9.49e-31: 122: 19.78
+	Hs
		844262 FXR2_HUMAN (268-525): 3.17e-50: 186: 30.56		HOME3_HUMAN (1-361): 2.61e-97: 294: 100.00
+	Hs
		844039 FXR2_HUMAN (268-525): 3.17e-50: 186: 30.56		CACO2_HUMAN (101-339): 6.54e-37: 140: 18.18
+	Hs
		844276 FXR2_HUMAN (268-525): 3.17e-50: 186: 30.56		EVL_HUMAN (4-178): 9.49e-31: 122: 19.78