Interactor 1: PRDX1 (Q06830)
Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)
Gene: PRDX1

Interactor 2: PRDX4 (Q13162)
Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4)
Gene: PRDX4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.914

The method score is based on:

Property Details
Experiments 9388242, 33961781, 34349018, 35235311, 21988832
Identification Methods two hybrid, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 1-cysPrx_C~1-cysPrx_C, 1-cysPrx_C~AhpC-TSA, AhpC-TSA~AhpC-TSA
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006979 - response to oxidative stress
GO:0008379 - thioredoxin peroxidase activity
GO:0042744 - hydrogen peroxide catabolic process
and 2 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 199
Hs

1 271
+ Hs
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+ Hs
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+ Hs
+ Hs
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+ Mm
+ Bt
+ Mm
+ Sp
+ At
+ Ss

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Last updated: 15 Jul 2024