HitPredict

Interactor 1: VAMP2 (P63027)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2

Interactor 2: ERGI3 (Q9Y282)
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84)
Gene: ERGIC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane GO:0090316 - positive regulation of intracellular protein transport
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 116 Hs			1 383
+	Hs
		662368 VAMP1_HUMAN (5-116): 1.61e-30: 107: 74.36		ERGI3_HUMAN (1-383): 0: 564: 100.00
+	Hs
		278582 VAMP4_HUMAN (18-99): 3.79e-27: 98.9: 35.37		ERGI3_HUMAN (1-383): 0: 564: 100.00
+	Hs
		1154787 VAMP3_HUMAN (26-98): 5.64e-25: 92.4: 91.78		ERGI3_HUMAN (1-383): 0: 564: 100.00
+	Hs
		328764 VAMP5_HUMAN (28-98): 2.31e-22: 85.9: 39.44		ERGI3_HUMAN (1-383): 0: 564: 100.00
+	Hs
		278548 VAMP4_HUMAN (18-99): 3.79e-27: 98.9: 35.37		ERGI2_HUMAN (2-380): 6.56e-117: 346: 32.19
+	Hs
		192301 YKT6_HUMAN (5-85): 5.35e-25: 95.1: 24.69		ERGI2_HUMAN (2-380): 6.56e-117: 346: 32.19
+	Hs
		328724 VAMP5_HUMAN (28-98): 2.31e-22: 85.9: 39.44		ERGI2_HUMAN (2-380): 6.56e-117: 346: 32.19
+	Zm
		31406 A0A1D6KH00_MAIZE (5-113): 3.3e-34: 125: 26.96		Q5EUD1_MAIZE (1-141): 2.05e-35: 137: 28.87
+	Hs
		192290 YKT6_HUMAN (5-85): 5.35e-25: 95.1: 24.69		ERGI1_HUMAN (7-109): 6.37e-27: 110: 34.91
+	Hs
		989368 VAMP2_HUMAN (25-116): 5.69e-26: 95.1: 100.00		ERGI1_HUMAN (7-109): 6.37e-27: 110: 34.91
+	Hs
		1154702 VAMP3_HUMAN (26-98): 5.64e-25: 92.4: 91.78		ERGI1_HUMAN (7-109): 6.37e-27: 110: 34.91