HitPredict

Interactor 1: I10R2 (Q08334)
Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
Gene: IL10RB

Interactor 2: IL22 (Q9GZX6)
Interleukin-22 (IL-22) (Cytokine Zcyto18) (IL-10-related T-cell-derived-inducible factor) (IL-TIF)
Gene: IL22

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	10875937, 20462497, 15120653, 12513909
Identification Methods	affinity chromatography technology, surface plasmon resonance, enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IL22~Interfer-bind, IL22~Tissue_fac
Common GO terms	GO:0006954 - inflammatory response
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 325 Hs			1 179
+	Hs
		1281607 I22R2_HUMAN (1-213): 1.82e-58: 190: 20.62		IL22_HUMAN (1-179): 5.46e-115: 325: 100.00
+	Hs
		819595 INAR2_HUMAN (1-322): 4.64e-52: 181: 15.32		IL22_HUMAN (1-179): 5.46e-115: 325: 100.00
+	Mm
		1194454 I22R2_MOUSE (23-213): 9.38e-55: 180: 24.14		IL22_MOUSE (1-179): 2.77e-113: 321: 78.21
+	Hs
		1236245 I22R1_HUMAN (25-319): 1.38e-47: 169: 17.32		IL22_HUMAN (1-179): 5.46e-115: 325: 100.00