HitPredict

Interactor 1: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	17389358, 14960283, 19201866
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0030674 - protein-macromolecule adaptor activity GO:0098978 - glutamatergic synapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 530 Mm			1 442
+	Rn
		81574 TRAF6_RAT (1-530): 1.67e-137: 409: 95.85		SQSTM_RAT (1-442): 0: 762: 97.06
+	Hs
		1108316 TRAF6_HUMAN (1-530): 2.33e-139: 414: 87.93		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Rn
		73339 B1WC90_RAT (54-515): 1.4e-88: 282: 25.47		SQSTM_RAT (1-442): 0: 762: 97.06
+	Hs
		1090626 TRAF2_HUMAN (38-508): 3.93e-101: 315: 25.55		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1094890 TRAF3_HUMAN (14-510): 3.16e-85: 276: 20.94		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1093807 TRAF1_HUMAN (50-511): 1.91e-64: 217: 18.63		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1108032 TRI11_HUMAN (59-418): 2.77e-48: 175: 12.91		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		323360 TRI37_HUMAN (56-519): 4.96e-46: 174: 14.83		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1107711 TRI25_HUMAN (63-387): 4.99e-43: 164: 13.39		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		623327 RO52_HUMAN (56-417): 2.01e-42: 159: 12.88		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1089195 TRI26_HUMAN (56-437): 1.51e-39: 152: 14.82		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1108004 RN166_HUMAN (61-194): 9.37e-15: 75.7: 23.53		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1108320 RN114_HUMAN (63-232): 2.74e-11: 65.3: 19.67		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Dm
		571083 Q9W3I9_DROME (7-508): 1.55e-66: 224: 23.88		REF2P_DROME (112-173): 2.25e-18: 89.4: 41.27
+	Hs
		342999 RN166_HUMAN (61-194): 9.37e-15: 75.7: 23.53		HERC2_HUMAN (120-197): 1.36e-11: 69: 32.50