Protein: RN114
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)

Gene: RN114, RNF114
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q9Y508

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982378

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.951

High

508897

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

20

Small-scale

0.930

High

906837

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.929

High

1331927

DTX3
Probable E3 ubiquitin-protein ligase DTX3

4

2

High-throughput

0.892

High

1491475

RN114
E3 ubiquitin-protein ligase RNF114

3

18

Small-scale

0.845

High

1382358

RN166
E3 ubiquitin-protein ligase RNF166

2

20

High-throughput

0.811

High

909418

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.800

High

957256

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.800

High

957696

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

1232909

XAF1
XIAP-associated factor 1

6

5

Small-scale

0.739

High

1447753

PAR11
Protein mono-ADP-ribosyltransferase PARP11

4

14

High-throughput

0.699

High

766054

BMI1
Polycomb complex protein BMI-1

1

18

High-throughput

0.698

High

971356

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1218773

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1381224

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1382559

TRI52
E3 ubiquitin-protein ligase TRIM52

1

20

High-throughput

0.698

High

1383950

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1397309

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.698

High

1419340

TRI55
Tripartite motif-containing protein 55

1

17

High-throughput

0.698

High

1491426

TRAF6
TNF receptor-associated factor 6

1

19

High-throughput

0.698

High

639335

TNAP3
Tumor necrosis factor alpha-induced protein 3

3

14

Small-scale

0.683

High

1430164

PAR12
Protein mono-ADP-ribosyltransferase PARP12

3

14

High-throughput

0.662

High

1490990

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.656

High

996049

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

High-throughput

0.647

High

1417242

IDI2
Isopentenyl-diphosphate delta-isomerase 2

3

0

High-throughput

0.634

High

1446633

C1QR1
Complement component C1q receptor

2

6

High-throughput

0.628

High

243400

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

1404874

RING2
E3 ubiquitin-protein ligase RING2

1

18

High-throughput

0.618

High

1448816

UBQL4
Ubiquilin-4

1

19

Small-scale

0.618

High

255896

USO1
General vesicular transport factor p115

2

6

High-throughput

0.611

High

1277034

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

2

14

High-throughput

0.611

High

1459449

ZRAN1
Ubiquitin thioesterase ZRANB1

2

17

High-throughput

0.584

High

1199187

PAR10
Protein mono-ADP-ribosyltransferase PARP10

2

14

Small-scale

0.571

High

535711

BIP
Endoplasmic reticulum chaperone BiP

1

16

Small-scale

0.561

High

476885

RSSA
Small ribosomal subunit protein uS2

1

4

High-throughput

0.541

High

1414813

TRAF4
TNF receptor-associated factor 4

1

19

High-throughput

0.541

High

1416109

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

8

High-throughput

0.541

High

1429976

RNF38
E3 ubiquitin-protein ligase RNF38

1

7

High-throughput

0.541

High

1491478

KAD5
Adenylate kinase isoenzyme 5

1

1

High-throughput

0.541

High

703255

HXD10
Homeobox protein Hox-D10

1

13

High-throughput

0.536

High

787600

TNR3
Tumor necrosis factor receptor superfamily member 3

1

20

High-throughput

0.536

High

1219824

PLPP4
Phospholipid phosphatase 4

1

3

High-throughput

0.536

High

1447500

ANLN
Anillin

1

4

High-throughput

0.536

High

75543

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1310072

U2D2L
Putative ubiquitin-conjugating enzyme E2 D2-like protein

1

20

High-throughput

0.528

High

652848

EVI2A
Protein EVI2A

1

0

High-throughput

0.518

High

967072

1433G
14-3-3 protein gamma

1

19

High-throughput

0.515

High

1139884

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

High-throughput

0.515

High

1347420

LMO3
LIM domain only protein 3

1

8

High-throughput

0.515

High

1371345

KAT5
Histone acetyltransferase KAT5

1

3

High-throughput

0.515

High

219531

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.513

High

949307

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.513

High

1281399

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.513

High

1491476

RAI2
Retinoic acid-induced protein 2

1

0

High-throughput

0.513

High

691882

MK03
Mitogen-activated protein kinase 3

1

5

High-throughput

0.508

High

1098871

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

18

Small-scale

0.501

High

1439026

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.501

High

1311680

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

8

High-throughput

0.494

High

377122

GLHA
Glycoprotein hormones alpha chain

1

1

High-throughput

0.489

High

536304

PPAL
Lysosomal acid phosphatase

1

1

High-throughput

0.489

High

1013361

HTRA4
Serine protease HTRA4

1

4

High-throughput

0.489

High

1400314

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

194632

KDM6A
Lysine-specific demethylase 6A

1

6

Small-scale

0.479

High

209705

SERA
D-3-phosphoglycerate dehydrogenase

1

2

Small-scale

0.479

High

260653

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

668766

APC
Adenomatous polyposis coli protein

1

11

Small-scale

0.479

High

714551

PML
Protein PML

1

20

High-throughput

0.479

High

808206

CDN1A
Cyclin-dependent kinase inhibitor 1

1

3

Small-scale

0.479

High

891917

GSK3B
Glycogen synthase kinase-3 beta

1

10

Small-scale

0.479

High

991788

DYL1
Dynein light chain 1, cytoplasmic

1

4

Small-scale

0.479

High

1033329

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

1108320

SQSTM
Sequestosome-1

1

14

High-throughput

0.479

High

1114754

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1137610

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1429897

TOLIP
Toll-interacting protein

1

2

Small-scale

0.479

High

1430011

SHRPN
Sharpin

1

6

Small-scale

0.479

High

1434336

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1447043

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

7

Small-scale

0.479

High

282199

MAF
Transcription factor Maf

1

0

Small-scale

0.458

High

927633

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

165839

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

5

High-throughput

0.445

High

190002

MOT7
Monocarboxylate transporter 7

1

4

High-throughput

0.445

High

190277

MOT4
Monocarboxylate transporter 4

1

4

High-throughput

0.445

High

190526

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.445

High

652272

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.445

High

844984

EAA2
Excitatory amino acid transporter 2

1

3

High-throughput

0.445

High

1040411

DYST
Dystonin

1

11

High-throughput

0.445

High

1411439

CAB45
45 kDa calcium-binding protein

1

3

High-throughput

0.445

High

1448594

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.445

High

1278159

MAVS
Mitochondrial antiviral-signaling protein

1

15

Small-scale

0.437

High

1172

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

1233730

TWF2
Twinfilin-2

1

3

High-throughput

0.407

High

1340587

MFSD8
Major facilitator superfamily domain-containing protein 8

1

3

High-throughput

0.407

High

1358044

TM171
Transmembrane protein 171

1

1

High-throughput

0.407

High

1412218

S35A5
UDP-sugar transporter protein SLC35A5

1

1

High-throughput

0.407

High

1449638

CBLN4
Cerebellin-4

1

5

High-throughput

0.407

High

1490694

SL9A8
Sodium/hydrogen exchanger 8

1

1

High-throughput

0.407

High

1491477

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

3

0

High-throughput

0.347

High

1429198

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025