Protein: TRI18
E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)

Gene: TRI18, MID1
Organism: Homo sapiens
Interactions: 118
UniProt ID: O15344

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005819 - spindle
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175623

TRI18
E3 ubiquitin-protein ligase Midline-1

13

19

Small-scale

0.981

High

175653

UB2D1
Ubiquitin-conjugating enzyme E2 D1

10

20

Small-scale

0.981

High

175658

UB2D3
Ubiquitin-conjugating enzyme E2 D3

10

20

Small-scale

0.978

High

175727

TRIM1
Probable E3 ubiquitin-protein ligase MID2

9

20

Small-scale

0.978

High

175664

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.967

High

175703

UB2E3
Ubiquitin-conjugating enzyme E2 E3

6

20

Small-scale

0.951

High

175730

UB2D4
Ubiquitin-conjugating enzyme E2 D4

4

20

Small-scale

0.896

High

175654

UB2E1
Ubiquitin-conjugating enzyme E2 E1

3

20

Small-scale

0.870

High

175710

UB2E2
Ubiquitin-conjugating enzyme E2 E2

7

20

Small-scale

0.865

High

175668

UB2L3
Ubiquitin-conjugating enzyme E2 L3

3

20

High-throughput

0.861

High

175659

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

High-throughput

0.845

High

175660

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

Small-scale

0.821

High

175633

IL6RA
Interleukin-6 receptor subunit alpha

2

16

High-throughput

0.811

High

158996

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

2

20

High-throughput

0.783

High

175714

UBTD1
Ubiquitin domain-containing protein 1

3

5

High-throughput

0.779

High

175672

IGBP1
Immunoglobulin-binding protein 1

14

2

Small-scale

0.761

High

175665

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

2

10

High-throughput

0.754

High

175684

PKN1
Serine/threonine-protein kinase N1

1

17

High-throughput

0.740

High

175720

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

11

High-throughput

0.740

High

175722

STK36
Serine/threonine-protein kinase 36

1

8

Small-scale

0.724

High

175675

Q0VDC6
peptidylprolyl isomerase

2

11

High-throughput

0.706

High

175677

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

175704

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

175651

MEOX1
Homeobox protein MOX-1

3

20

High-throughput

0.683

High

175708

GMCL1
Germ cell-less protein-like 1

5

19

High-throughput

0.655

High

175674

ECHP
Peroxisomal bifunctional enzyme

3

17

High-throughput

0.654

High

175667

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

11

Small-scale

0.651

High

175683

PTPA
Serine/threonine-protein phosphatase 2A activator

3

1

Small-scale

0.647

High

175628

STBD1
Starch-binding domain-containing protein 1

3

0

High-throughput

0.638

High

175713

EPN3
Epsin-3

4

17

High-throughput

0.634

High

70958

ZBT42
Zinc finger and BTB domain-containing protein 42

2

20

High-throughput

0.628

High

175626

GEMI
Geminin

2

2

High-throughput

0.628

High

175647

GSTT1
Glutathione S-transferase theta-1

2

2

High-throughput

0.628

High

175716

ZFYV1
Zinc finger FYVE domain-containing protein 1

2

20

High-throughput

0.628

High

175679

BYST
Bystin

2

8

High-throughput

0.628

High

50877

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

19

High-throughput

0.618

High

175717

LRRC4
Leucine-rich repeat-containing protein 4

1

7

High-throughput

0.618

High

171271

EPHB6
Ephrin type-B receptor 6

1

15

High-throughput

0.618

High

175634

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.618

High

175666

RACK1
Small ribosomal subunit protein RACK1

1

12

Small-scale

0.618

High

175691

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

175698

LNX1
E3 ubiquitin-protein ligase LNX

1

17

Small-scale

0.618

High

175702

ESR2
Estrogen receptor beta

1

17

High-throughput

0.618

High

175706

PDLI5
PDZ and LIM domain protein 5

1

18

Small-scale

0.618

High

175718

M1IP1
Mid1-interacting protein 1

2

2

Small-scale

0.611

High

175625

N4BP1
NEDD4-binding protein 1

2

5

High-throughput

0.606

High

175627

EPN2
Epsin-2

2

11

High-throughput

0.606

High

175685

CDC37
Hsp90 co-chaperone Cdc37

2

3

High-throughput

0.606

High

175715

KIF9
Kinesin-like protein KIF9

2

20

High-throughput

0.606

High

175635

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.590

High

175646

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

8

Small-scale

0.584

High

175725

TBA8
Tubulin alpha-8 chain

2

20

High-throughput

0.584

High

175687

CRY2
Cryptochrome-2

2

0

High-throughput

0.580

High

175689

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

15

High-throughput

0.575

High

175655

AF17
Protein AF-17

2

6

High-throughput

0.574

High

175642

PAX6
Paired box protein Pax-6

1

4

Small-scale

0.561

High

175648

PPM1A
Protein phosphatase 1A

1

2

Small-scale

0.561

High

175711

SPAG5
Sperm-associated antigen 5

1

20

Small-scale

0.561

High

175719

RIC8A
Synembryn-A

1

1

Small-scale

0.561

High

175680

ELOA1
Elongin-A

2

13

High-throughput

0.553

High

175690

ZN618
Zinc finger protein 618

2

14

High-throughput

0.553

High

175700

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

2

2

High-throughput

0.553

High

175729

FA50B
Protein FAM50B

2

5

High-throughput

0.553

High

175669

EF1A1
Elongation factor 1-alpha 1

1

7

Small-scale

0.552

High

175636

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

2

High-throughput

0.536

High

175656

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

13

High-throughput

0.536

High

175673

IRF8
Interferon regulatory factor 8

1

14

High-throughput

0.536

High

175686

VATF
V-type proton ATPase subunit F

1

1

High-throughput

0.536

High

175696

EIF1A
Probable RNA-binding protein EIF1AD

1

1

High-throughput

0.536

High

175723

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

4

High-throughput

0.536

High

175731

SAR1B
Small COPII coat GTPase SAR1B

1

13

High-throughput

0.536

High

72133

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

175726

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

14

Small-scale

0.528

High

175695

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

1

20

High-throughput

0.523

High

175705

OTUB2
Ubiquitin thioesterase OTUB2

1

14

High-throughput

0.523

High

49186

TLDC2
TLD domain-containing protein 2

1

4

High-throughput

0.489

High

175694

SYCE1
Synaptonemal complex central element protein 1

1

1

High-throughput

0.489

High

175697

ZN784
Zinc finger protein 784

1

20

High-throughput

0.489

High

175699

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

2

High-throughput

0.489

High

175724

CARF
CDKN2A-interacting protein

1

3

High-throughput

0.489

High

175728

TF3C4
General transcription factor 3C polypeptide 4

1

1

High-throughput

0.489

High

130646

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

16

Small-scale

0.479

High

175624

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

5

Small-scale

0.479

High

175629

NPM
Nucleophosmin

1

4

Small-scale

0.479

High

175630

ANXA2
Annexin A2

1

13

Small-scale

0.479

High

175631

TBB5
Tubulin beta chain

1

20

Small-scale

0.479

High

175632

HS90A
Heat shock protein HSP 90-alpha

1

12

Small-scale

0.479

High

175637

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

175638

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

17

Small-scale

0.479

High

175639

PSB1
Proteasome subunit beta type-1

1

20

Small-scale

0.479

High

175640

RS3
Small ribosomal subunit protein uS3

1

3

Small-scale

0.479

High

175641

PSA1
Proteasome subunit alpha type-1

1

16

Small-scale

0.479

High

175643

PSB4
Proteasome subunit beta type-4

1

20

Small-scale

0.479

High

175644

PSB6
Proteasome subunit beta type-6

1

15

Small-scale

0.479

High

175645

PSB5
Proteasome subunit beta type-5

1

16

Small-scale

0.479

High

175649

PRS7
26S proteasome regulatory subunit 7

1

16

Small-scale

0.479

High

175652

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

9

Small-scale

0.479

High

175657

PSA6
Proteasome subunit alpha type-6

1

18

Small-scale

0.479

High

175661

PRS4
26S proteasome regulatory subunit 4

1

15

Small-scale

0.479

High

175662

RS8
Small ribosomal subunit protein eS8

1

2

Small-scale

0.479

High

175663

PRS10
26S proteasome regulatory subunit 10B

1

20

Small-scale

0.479

High

175670

TBA1B
Tubulin alpha-1B chain

1

20

Small-scale

0.479

High

175671

TBB4B
Tubulin beta-4B chain

1

20

Small-scale

0.479

High

175676

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

9

Small-scale

0.479

High

175678

CUL3
Cullin-3

1

20

High-throughput

0.479

High

175681

IRF3
Interferon regulatory factor 3

1

14

Small-scale

0.479

High

175682

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

175692

ZN598
E3 ubiquitin-protein ligase ZNF598

1

14

High-throughput

0.479

High

175701

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

18

High-throughput

0.479

High

175707

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

111205

I6L9I8
EPN3 protein

1

10

High-throughput

0.470

High

175688

Q53SE7
Germ cell-less homolog 1

1

19

High-throughput

0.470

High

175712

ATGA1
Autophagy-related protein 101

1

0

Small-scale

0.458

High

175721

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

175650

INAR2
Interferon alpha/beta receptor 2

1

3

Small-scale

0.437

High

175693

GRP3
Ras guanyl-releasing protein 3

1

3

Small-scale

0.437

High

175709

F167A
Protein FAM167A

2

0

High-throughput

0.328

High


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Last updated: 15 Jul 2024