Protein: TOP2B
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)

Gene: TOP2B
Organism: Homo sapiens
Interactions: 220
UniProt ID: Q02880

Gene Ontology (top 5):
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000819 - sister chromatid segregation
GO:0001764 - neuron migration
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508952

TOP2A
DNA topoisomerase 2-alpha

2

16

Small-scale

0.799

High

973338

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.691

High

455340

PARP1
Poly [ADP-ribose] polymerase 1

4

4

Small-scale

0.686

High

973377

CUL5
Cullin-5

3

5

High-throughput

0.675

High

973363

PIAS4
E3 SUMO-protein ligase PIAS4

2

3

Small-scale

0.639

High

930154

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.636

High

973327

HDAC1
Histone deacetylase 1

2

4

Small-scale

0.636

High

642827

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

1

High-throughput

0.628

High

973422

ASB3
Ankyrin repeat and SOCS box protein 3

2

3

High-throughput

0.628

High

386566

P53
Cellular tumor antigen p53

2

2

Small-scale

0.624

High

973390

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.618

High

369444

ESR1
Estrogen receptor

2

11

Small-scale

0.611

High

489010

H14
Histone H1.4

2

1

High-throughput

0.611

High

940801

RNF4
E3 ubiquitin-protein ligase RNF4

2

1

Small-scale

0.595

High

931594

CSK2B
Casein kinase II subunit beta

2

2

Small-scale

0.586

High

244311

BRD4
Bromodomain-containing protein 4

2

12

High-throughput

0.584

High

322503

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

10

High-throughput

0.584

High

346573

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

552537

RFA2
Replication protein A 32 kDa subunit

2

3

High-throughput

0.584

High

651003

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

720272

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.584

High

918302

H2B1C
Histone H2B type 1-C/E/F/G/I

2

13

High-throughput

0.584

High

934678

H31
Histone H3.1

2

12

High-throughput

0.584

High

973332

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

8

High-throughput

0.584

High

487950

RARA
Retinoic acid receptor alpha

1

9

Small-scale

0.561

High

507402

ERG
Transcriptional regulator ERG

1

1

Small-scale

0.561

High

834720

RBP2
E3 SUMO-protein ligase RanBP2

1

2

Small-scale

0.561

High

973374

HDAC2
Histone deacetylase 2

1

5

Small-scale

0.561

High

921227

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

Small-scale

0.559

High

607810

USF1
Upstream stimulatory factor 1

1

4

Small-scale

0.554

High

804210

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.554

High

364867

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

418190

NPM
Nucleophosmin

1

2

High-throughput

0.536

High

449687

HMGB1
High mobility group protein B1

1

7

High-throughput

0.536

High

470003

H2AZ
Histone H2A.Z

1

9

High-throughput

0.536

High

508466

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

564870

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

620480

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

2

High-throughput

0.536

High

649470

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

739077

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.536

High

805966

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

907856

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

942605

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.536

High

948780

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

1

High-throughput

0.536

High

949758

CBX1
Chromobox protein homolog 1

1

3

High-throughput

0.536

High

973317

CALD1
Caldesmon

1

7

High-throughput

0.536

High

973318

SSRP1
FACT complex subunit SSRP1

1

13

High-throughput

0.536

High

973329

CAPR1
Caprin-1

1

3

High-throughput

0.536

High

973333

NUMA1
Nuclear mitotic apparatus protein 1

1

3

High-throughput

0.536

High

973343

H2B2E
Histone H2B type 2-E

1

13

High-throughput

0.536

High

973347

DJC21
DnaJ homolog subfamily C member 21

1

1

High-throughput

0.536

High

973352

MED27
Mediator of RNA polymerase II transcription subunit 27

1

1

High-throughput

0.536

High

973357

COX15
Heme A synthase COX15

1

1

High-throughput

0.536

High

973367

NECP1
Adaptin ear-binding coat-associated protein 1

1

1

High-throughput

0.536

High

973371

PSPC1
Paraspeckle component 1

1

8

High-throughput

0.536

High

973379

TRI52
E3 ubiquitin-protein ligase TRIM52

1

1

High-throughput

0.536

High

973388

VRK1
Serine/threonine-protein kinase VRK1

1

2

High-throughput

0.536

High

973396

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

973398

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

973410

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

973411

FOXD3
Forkhead box protein D3

1

8

High-throughput

0.536

High

973414

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.536

High

973418

KLH20
Kelch-like protein 20

1

2

High-throughput

0.536

High

973420

ZN451
E3 SUMO-protein ligase ZNF451

1

1

High-throughput

0.536

High

973384

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.528

High

523684

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.515

High

973385

MED15
Mediator of RNA polymerase II transcription subunit 15

1

3

High-throughput

0.515

High

828743

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

873533

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.513

High

475645

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

749396

BRCA1
Breast cancer type 1 susceptibility protein

1

3

Small-scale

0.501

High

902535

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

973376

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

790661

WASP
Actin nucleation-promoting factor WAS

1

3

Small-scale

0.484

High

928069

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.481

High

973373

TOPB1
DNA topoisomerase 2-binding protein 1

1

4

Small-scale

0.481

High

92212

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

973331

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

973334

CUL7
Cullin-7

1

2

High-throughput

0.479

High

973335

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

973336

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

973337

BRD3
Bromodomain-containing protein 3

1

16

High-throughput

0.479

High

973339

ZMY11
Zinc finger MYND domain-containing protein 11

1

7

Small-scale

0.479

High

119336

LEG9
Galectin-9

1

2

High-throughput

0.479

High

122680

MEN1
Menin

1

2

High-throughput

0.479

High

125393

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

130854

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

Small-scale

0.479

High

133449

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

148702

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

179608

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

209907

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

227219

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

233382

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

233829

HBP1
HMG box-containing protein 1

1

10

High-throughput

0.479

High

241507

H2B1K
Histone H2B type 1-K

1

13

High-throughput

0.479

High

255700

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.479

High

295991

MTA2
Metastasis-associated protein MTA2

1

3

Small-scale

0.479

High

308629

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

359866

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

High-throughput

0.479

High

384679

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

397920

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.479

High

433708

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.479

High

435053

SP1
Transcription factor Sp1

1

1

Small-scale

0.479

High

442086

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

487348

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

603460

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

631406

BRD2
Bromodomain-containing protein 2

1

14

High-throughput

0.479

High

636895

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

652822

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

656700

PSB5
Proteasome subunit beta type-5

1

2

Small-scale

0.479

High

668609

PML
Protein PML

1

5

Small-scale

0.479

High

684647

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

740506

PPARG
Peroxisome proliferator-activated receptor gamma

1

10

Small-scale

0.479

High

750231

COIL
Coilin

1

1

High-throughput

0.479

High

779271

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

790369

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

813395

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

823908

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

828199

CENPA
Histone H3-like centromeric protein A

1

12

High-throughput

0.479

High

830931

CTCF
Transcriptional repressor CTCF

1

1

Small-scale

0.479

High

850007

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

852443

RND2
Rho-related GTP-binding protein RhoN

1

9

High-throughput

0.479

High

877246

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

10

High-throughput

0.479

High

880902

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

893918

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

899721

RL27
Large ribosomal subunit protein eL27

1

2

High-throughput

0.479

High

900396

RHOA
Transforming protein RhoA

1

7

High-throughput

0.479

High

915620

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.479

High

916533

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

917140

H4
Histone H4

1

3

High-throughput

0.479

High

920153

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

922131

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

944748

RED1
Double-stranded RNA-specific editase 1

1

9

High-throughput

0.479

High

952283

H33
Histone H3.3

1

12

High-throughput

0.479

High

969627

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

973315

ERCC6
DNA excision repair protein ERCC-6

1

14

Small-scale

0.479

High

973319

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

973320

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

8

High-throughput

0.479

High

973321

FOXC1
Forkhead box protein C1

1

10

High-throughput

0.479

High

973322

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.479

High

973323

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

973324

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.479

High

973325

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

973326

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

973341

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

973342

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

973345

MIDN
Midnolin

1

1

High-throughput

0.479

High

973346

PDCD4
Programmed cell death protein 4

1

1

High-throughput

0.479

High

973349

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.479

High

973350

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

973351

H3C
Histone H3.3C

1

12

High-throughput

0.479

High

973359

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

973360

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

973361

SRRM1
Serine/arginine repetitive matrix protein 1

1

3

High-throughput

0.479

High

973365

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

973366

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

973368

NUP43
Nucleoporin Nup43

1

12

High-throughput

0.479

High

973369

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

973370

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

973372

DDB2
DNA damage-binding protein 2

1

10

High-throughput

0.479

High

973375

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.479

High

973378

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

973380

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

973381

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

973382

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.479

High

973383

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.479

High

973386

BARD1
BRCA1-associated RING domain protein 1

1

2

Small-scale

0.479

High

973387

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

11

High-throughput

0.479

High

973389

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.479

High

973391

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

973393

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

6

High-throughput

0.479

High

973400

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

973401

RHOF
Rho-related GTP-binding protein RhoF

1

7

High-throughput

0.479

High

973402

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.479

High

973404

ANLN
Anillin

1

1

High-throughput

0.479

High

973405

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

973406

NLE1
Notchless protein homolog 1

1

4

High-throughput

0.479

High

973412

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.479

High

973415

CE164
Centrosomal protein of 164 kDa

1

5

High-throughput

0.479

High

973417

FBW1A
F-box/WD repeat-containing protein 1A

1

5

Small-scale

0.479

High

973419

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

973421

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

206352

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.460

High

265319

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.458

High

278792

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

617744

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.458

High

822245

KC1D
Casein kinase I isoform delta

1

0

Small-scale

0.458

High

973330

BECN1
Beclin-1

1

0

Small-scale

0.458

High

973344

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

973353

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.458

High

973356

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

973395

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

973403

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.458

High

973408

DYH2
Dynein axonemal heavy chain 2

1

0

High-throughput

0.458

High

973416

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

973423

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

401871

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

853864

NCBP2
Nuclear cap-binding protein subunit 2

1

8

High-throughput

0.445

High

973316

KPCD
Protein kinase C delta type

1

6

Small-scale

0.445

High

973328

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.445

High

973348

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.445

High

973407

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

973413

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.445

High

297606

RHBT1
Rho-related BTB domain-containing protein 1

1

9

High-throughput

0.437

High

973340

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.437

High

973355

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

973358

OTU6A
OTU domain-containing protein 6A

1

1

Small-scale

0.437

High

973362

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.437

High

973392

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

973394

RHBT2
Rho-related BTB domain-containing protein 2

1

9

High-throughput

0.437

High

973397

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.437

High

973399

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

973364

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

831242

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

56609

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

973314

UPAR
Urokinase plasminogen activator surface receptor

2

0

High-throughput

0.328

High

430695

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

Small-scale

0.292

High

261653

VAMP4
Vesicle-associated membrane protein 4

1

0

High-throughput

0.269

Low

973354

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

973409

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024